Co-Exposure of Ambient Particulate Matter and Airborne Transmission Pathogens: The Impairment of the Upper Respiratory Systems
文献类型：期刊论文
| 作者 | Qi, Yu ; Chen, Yucai; Yan, Xu; Liu, Wei; Ma, Li; Liu, Yongchun; Ma, Qingxin; Liu, Sijin
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| 刊名 | ENVIRONMENTAL SCIENCE & TECHNOLOGY
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| 出版日期 | 2022 |
| 页码 | 1-10 |
| ISSN号 | 0013-936X |
| 关键词 | particulate matter pathogens inhalation system upper respiratory tract inflammation |
| 英文摘要 | Recent evidence has pinpointed the positive relevance between air particulate matter (PM) pollution and epidemic spread. However, there are still significant knowledge gaps in understanding the transmission and infection of pathogens loaded on PMs, for example, the interactions between pathogens and pre-existing atmospheric PM and the health effects of co-exposure on the inhalation systems. Here, we unraveled the interactions between fine particulate matter (FPM) and Pseudomonas aeruginosa (P. aeruginosa) and evaluated the infection and detrimental effects of co-exposure on the upper respiratory systems in both in vitro and in vivo models. We uncovered the higher accessibility and invasive ability of pathogens to epithelial cells after loading on FPMs, compared with the single exposure. Furthermore, we designed a novel laboratory exposure model to simulate a real co-exposure scenario. Intriguingly, the co exposure induced more serious functional damage and longer inflammatory reactions to the upper respiratory tract, including the nasal cavity and trachea. Collectively, our results provide a new point of view on the transmission and infection of pathogens loaded on FPMs and uncover the in vivo systematic impairments of the inhalation tract under co-exposure through a novel laboratory exposure model. Hence, this study sheds light on further investigations of the detrimental effects of air pollution and epidemic spread. |
| 源URL | [https://ir.rcees.ac.cn/handle/311016/48480]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 作者单位 | 1.University of Chinese Academy of Sciences, CAS 2.Chinese Academy of Sciences 3.Research Center for Eco-Environmental Sciences (RCEES) 4.Beijing University of Chemical Technology |
| 推荐引用方式 GB/T 7714 | Qi, Yu,Chen, Yucai,Yan, Xu,et al. Co-Exposure of Ambient Particulate Matter and Airborne Transmission Pathogens: The Impairment of the Upper Respiratory Systems[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2022:1-10. |
| APA | Qi, Yu.,Chen, Yucai.,Yan, Xu.,Liu, Wei.,Ma, Li.,...&Liu, Sijin.(2022).Co-Exposure of Ambient Particulate Matter and Airborne Transmission Pathogens: The Impairment of the Upper Respiratory Systems.ENVIRONMENTAL SCIENCE & TECHNOLOGY,1-10. |
| MLA | Qi, Yu,et al."Co-Exposure of Ambient Particulate Matter and Airborne Transmission Pathogens: The Impairment of the Upper Respiratory Systems".ENVIRONMENTAL SCIENCE & TECHNOLOGY (2022):1-10. |
入库方式： OAI收割
来源：生态环境研究中心
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