Effects of the emerging contaminant 1,3,6,8-tetrabromocarbazole on the NF-?B and correlated mechanism in human hepatocellular carcinoma cells
文献类型：期刊论文
| 作者 | Xu, Tong ; Jiang, Yu; Hu, Xiaoxu; Yang, Guanglei; Chen, Yangsheng; Zhang, Songyan; Zhang, Qian; Zheng, Liping; Xie, Heidi Qunhui; Xu, Li
|
| 刊名 | ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
 |
| 出版日期 | 2022 |
| 卷号 | 247页码:114199-1-7 |
| 关键词 | 1 3 6 8-Tetrabromocarbazole NF-xB Apoptosis HepG2 cells |
| ISSN号 | 0147-6513 |
| 英文摘要 | 1,3,6,8-Tetrabromocarbazole (1368-BCZ) is identified as an emerging contaminant that exerts angiogenic effects. Multiple studies indicated there was a positive correlation between angiogenesis and nuclear factor kappa B (NFxB) activation. While the role of NF-xB in inflammation and apoptosis has been well known, the potential biological effects of 1368-BCZ on NF-xB signaling and related mechanism remain unclear. We, therefore, explored the possible effects of 1368-BCZ on the NF-xB pathway at the gene and protein levels and confirmed that NF-xB activation by 1368-BCZ exposure caused an augmented phosphorylated protein level, induction of NF-xB response element (xBRE)-driven luciferase activity and upregulation of transcriptional level of downstream responsive genes. Although 1368-BCZ did not produce detectable changes in hepatic fibrosis in vivo, it obviously altered the apoptosis in human hepatocellular carcinoma (HepG2) cells. Furthermore, the induction of apoptosis was confirmed by the increased cleaved caspase-3 level. These data revealed the activating effects of 1368-BCZ on NF-xB and its involvement in the underlying mechanisms, providing additional information for toxicology studies of emerging contaminants and introducing a mechanism-based toxicological evaluation of emerging pollutants. |
| 源URL | [https://ir.rcees.ac.cn/handle/311016/48487]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 作者单位 | 1.Fujian Medical University 2.Chinese Academy of Sciences 3.Research Center for Eco-Environmental Sciences (RCEES) 4.University of Chinese Academy of Sciences, CAS 5.Shenzhen University 6.Beijing Hospital |
| 推荐引用方式 GB/T 7714 | Xu, Tong,Jiang, Yu,Hu, Xiaoxu,et al. Effects of the emerging contaminant 1,3,6,8-tetrabromocarbazole on the NF-?B and correlated mechanism in human hepatocellular carcinoma cells[J]. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,2022,247:114199-1-7. |
| APA | Xu, Tong.,Jiang, Yu.,Hu, Xiaoxu.,Yang, Guanglei.,Chen, Yangsheng.,...&Zhao, Bin.(2022).Effects of the emerging contaminant 1,3,6,8-tetrabromocarbazole on the NF-?B and correlated mechanism in human hepatocellular carcinoma cells.ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,247,114199-1-7. |
| MLA | Xu, Tong,et al."Effects of the emerging contaminant 1,3,6,8-tetrabromocarbazole on the NF-?B and correlated mechanism in human hepatocellular carcinoma cells".ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY 247(2022):114199-1-7. |
入库方式： OAI收割
来源：生态环境研究中心
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。