Extra-Pulmonary Translocation of Exogenous Ambient Nanoparticles in the Human Body
文献类型：期刊论文
| 作者 | Qi, Yu ; Chen, Yucai; Xia, Tian; Lynch, Iseult; Liu, Sijin
|
| 刊名 | ACS NANO
 |
| 出版日期 | 2022 |
| 页码 | 1-8 |
| 关键词 | air pollution particulate matter biodistribution health risks retention and clearance kinetics |
| ISSN号 | 1936-0851 |
| 英文摘要 | As one of the major pollutants in the air, ambient fine particles are gaining considerable attention in terms of public health concerns. Significant progress has been achieved in recent years in understanding the biological effects and mechanisms of ambient fine particles. The airborne particles can enter the human body through various pathways and translocate to a range of different organs and further stay in these organs for extended periods. Current studies are making substantial achievements, while many challenges remain. On one hand, the whole picture of the concurrent exposure pathways and the translocation of particles in the human body should be explored, requiring technological advances and systematic biobanking of human samples for analysis. On the other hand, the correlation between the environmental exposure concentration of ambient particles and internal fate (i.e., dose, distribution patterns, and kinetics) of invasive particles needs to be investigated. Moreover, the biotransformation of particles in vivo should be considered, and more information is needed to differentiate exogenous particles from biological macromolecules and biogenically formed particles. We recapitulate the current knowledge gaps in understanding the fate of exogenous ambient fine particles in extra pulmonary organs of the human body and the related biological effects and also propose future research directions to support both fundamental studies and policy making. |
| 源URL | [https://ir.rcees.ac.cn/handle/311016/48491]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 作者单位 | 1.Shandong First Medical University & Shandong Academy of Medical Sciences 2.University of Jinan 3.University of California Los Angeles 4.University of California System 5.Chinese Academy of Sciences 6.University of Chinese Academy of Sciences, CAS 7.Research Center for Eco-Environmental Sciences (RCEES) 8.University of Birmingham |
| 推荐引用方式 GB/T 7714 | Qi, Yu,Chen, Yucai,Xia, Tian,et al. Extra-Pulmonary Translocation of Exogenous Ambient Nanoparticles in the Human Body[J]. ACS NANO,2022:1-8. |
| APA | Qi, Yu,Chen, Yucai,Xia, Tian,Lynch, Iseult,&Liu, Sijin.(2022).Extra-Pulmonary Translocation of Exogenous Ambient Nanoparticles in the Human Body.ACS NANO,1-8. |
| MLA | Qi, Yu,et al."Extra-Pulmonary Translocation of Exogenous Ambient Nanoparticles in the Human Body".ACS NANO (2022):1-8. |
入库方式： OAI收割
来源：生态环境研究中心
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