Intramolecular Folding of PolyT Oligonucleotides Induced by Cooperative Binding of Silver(I) Ions
文献类型：期刊论文
| 作者 | Hao, Jinghua; Cao, Dong ; Zhao, Qiang; Zhang, Dapeng; Wang, Hailin
|
| 刊名 | MOLECULES
 |
| 出版日期 | 2022 |
| 卷号 | 27期号:22页码:7842-1-14 |
| 关键词 | cooperative binding DNA intramolecular folding metal-mediated base pairs silver ions |
| 英文摘要 | Ag+-bridged T-Ag+-T was recently discovered in a Ag+-DNA nanowire crystal, but it was reported that Ag+ had little to no affinity to T nucleobases and T-rich oligonucleotides in solution. Therefore, the binding mode for the formation of this type of novel metallo base pair in solution is elusive. Herein, we demonstrate that Ag+ can interact with polyT oligonucleotides once the concentration of Ag+ in solution exceeds a threshold value. The threshold value is independent of the concentration of the polyT oligonucleotide but is inversely proportional to the length of the polyT oligonucleotide. The polyT oligonucleotides are intramolecularly folded due to their positively cooperative formation and the stack of T-Ag+-T base pairs, resulting in the 5 '- and 3 '-ends being in close proximity to each other. The intramolecular Ag+-folded polyT oligonucleotide has a higher thermal stability than the duplex and can be reversibly modulated by cysteine. |
| 源URL | [https://ir.rcees.ac.cn/handle/311016/48496]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 作者单位 | 1.University of Chinese Academy of Sciences, CAS 2.Chinese Academy of Sciences 3.Research Center for Eco-Environmental Sciences (RCEES) |
| 推荐引用方式 GB/T 7714 | Hao, Jinghua,Cao, Dong,Zhao, Qiang,et al. Intramolecular Folding of PolyT Oligonucleotides Induced by Cooperative Binding of Silver(I) Ions[J]. MOLECULES,2022,27(22):7842-1-14. |
| APA | Hao, Jinghua,Cao, Dong,Zhao, Qiang,Zhang, Dapeng,&Wang, Hailin.(2022).Intramolecular Folding of PolyT Oligonucleotides Induced by Cooperative Binding of Silver(I) Ions.MOLECULES,27(22),7842-1-14. |
| MLA | Hao, Jinghua,et al."Intramolecular Folding of PolyT Oligonucleotides Induced by Cooperative Binding of Silver(I) Ions".MOLECULES 27.22(2022):7842-1-14. |
入库方式： OAI收割
来源：生态环境研究中心
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