Lactate: A pearl dropped in the ocean: An overlooked signal molecule in physiology and pathology
文献类型：期刊论文
| 作者 | Wu, Yue ; Ma, Wanqi; Liu, Wei; Zhang, Shuping
|
| 刊名 | CELL BIOLOGY INTERNATIONAL
 |
| 出版日期 | 2023 |
| 卷号 | 47期号:2页码:1-13 |
| 关键词 | cancer immunomodulation infection lactate signal molecule |
| ISSN号 | 1065-6995 |
| 英文摘要 | Lactate, once recognized as a wasty product from anaerobic glycolysis, is proved to be a pivotal signal molecule. Lactate accumulation occurs in diverse physiological and pathological settings due to the imbalance between lactate production and clearance. Under the condition with drastic changes in local microenvironment, such as tumorigenesis, inflammation, and microbial infection, the glycolysis turns to be active in surrounding cells leading to increased lactate release. Meanwhile, lactate can be utilized by these cells as an energy substrate and acts as a signal molecule to regulate cell functions through receptor-dependent or independent pathways. In this review, we tended to tease out the contribution of lactate in tumor progression and immunomodulation. And we also discussed the accessory role of lactate, beyond as the energy source only, in the growth of invading pathogens. |
| 源URL | [https://ir.rcees.ac.cn/handle/311016/48498]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 作者单位 | 1.Shandong First Medical University & Shandong Academy of Medical Sciences 2.University of Chinese Academy of Sciences, CAS 3.Chinese Academy of Sciences 4.University of Jinan 5.Research Center for Eco-Environmental Sciences (RCEES) |
| 推荐引用方式 GB/T 7714 | Wu, Yue,Ma, Wanqi,Liu, Wei,et al. Lactate: A pearl dropped in the ocean: An overlooked signal molecule in physiology and pathology[J]. CELL BIOLOGY INTERNATIONAL,2023,47(2):1-13. |
| APA | Wu, Yue,Ma, Wanqi,Liu, Wei,&Zhang, Shuping.(2023).Lactate: A pearl dropped in the ocean: An overlooked signal molecule in physiology and pathology.CELL BIOLOGY INTERNATIONAL,47(2),1-13. |
| MLA | Wu, Yue,et al."Lactate: A pearl dropped in the ocean: An overlooked signal molecule in physiology and pathology".CELL BIOLOGY INTERNATIONAL 47.2(2023):1-13. |
入库方式： OAI收割
来源：生态环境研究中心
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