Polystyrene Microplastics Postpone APAP-Induced Liver Injury through Impeding Macrophage Polarization
文献类型：期刊论文
| 作者 | Liu, Jing ; Zhang, Lecong; Xu, Fang; Meng, Songyan; Li, Haitian; Song, Yang
|
| 刊名 | TOXICS
 |
| 出版日期 | 2022 |
| 卷号 | 10期号:12页码:792-1-12 |
| 关键词 | polystyrene microplastics acetaminophen inflammation macrophage polarization |
| 英文摘要 | Polystyrene microplastics (PS MPs) are micrometer-scale items degraded from plastics and have been detected in various organisms. PS MPs have been identified as causing cognitive, cardiac, intestinal, and hepatic damage. However, their role in liver regeneration under drug-induced liver injury remains unknown. Thus, the current study aims to evaluate the impact of PS MPs on liver repair during APAP hepatotoxicity. PS MPs pretreatment exacerbates mice mortality and hepatocyte apoptosis, suppresses hepatic cell proliferation, and disturbs the inflammatory response in the APAP-induced damage model. Further mechanism exploration uncovers that prior PS MPs administration is sufficient to recruit neutrophils and macrophages, which are necessary for tissue recovery in the acute liver injury model. However, the polarization capacity of macrophages to anti-inflammatory sub-type is significantly delayed in PS MPs plus APAP group compared to the single APAP group, which is the leading cause of tissue repair suppression. Overall, the current study supports a new insight to realize the toxicity of PS MPs in acute liver injury, which should be considered in health risk assessment. |
| 源URL | [https://ir.rcees.ac.cn/handle/311016/48510]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 作者单位 | 1.Chinese Academy of Sciences 2.Guizhou Minzu University 3.Research Center for Eco-Environmental Sciences (RCEES) |
| 推荐引用方式 GB/T 7714 | Liu, Jing,Zhang, Lecong,Xu, Fang,et al. Polystyrene Microplastics Postpone APAP-Induced Liver Injury through Impeding Macrophage Polarization[J]. TOXICS,2022,10(12):792-1-12. |
| APA | Liu, Jing,Zhang, Lecong,Xu, Fang,Meng, Songyan,Li, Haitian,&Song, Yang.(2022).Polystyrene Microplastics Postpone APAP-Induced Liver Injury through Impeding Macrophage Polarization.TOXICS,10(12),792-1-12. |
| MLA | Liu, Jing,et al."Polystyrene Microplastics Postpone APAP-Induced Liver Injury through Impeding Macrophage Polarization".TOXICS 10.12(2022):792-1-12. |
入库方式： OAI收割
来源：生态环境研究中心
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