Lead Exposure Causes Spinal Curvature during Embryonic Development in Zebrafish
文献类型：期刊论文
| 作者 | Li, Xueting; Chen, Ce; He, Mingyue; Yu, Lidong; Liu, Renhao; Ma, Chunmeng ; Zhang, Yu; Jia, Jianbo; Li, Bingsheng; Li, Li
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| 刊名 | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
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| 出版日期 | 2022-09-01 |
| 卷号 | 23期号:17页码:9571 |
| 关键词 | TOXICITY |
| 英文摘要 | Lead (Pb) is an important raw material for modern industrial production, they enter the aquatic environment in several ways and cause serious harm to aquatic ecosystems. Lead ions (Pb2+) are highly toxic and can accumulate continuously in organisms. In addition to causing biological deaths, it can also cause neurological damage in vertebrates. Our experiment found that Pb2+ caused decreased survival, delayed hatching, decreased frequency of voluntary movements at 24 hpf, increased heart rate at 48 hpf and increased malformation rate in zebrafish embryos. Among them, the morphology of spinal malformations varied, with 0.4 mg/L Pb2+ causing a dorsal bending of the spine of 72 hpf zebrafish and a ventral bending in 120 hpf zebrafish. It was detected that spinal malformations were mainly caused by Pb2+-induced endoplasmic reticulum stress and apoptosis. The genetic changes in somatic segment development which disrupted developmental polarity as well as osteogenesis, resulting in uneven myotomal development. In contrast, calcium ions can rescue the series of responses induced by lead exposure and reduce the occurrence of spinal curvature. This article proposes new findings of lead pollution toxicity in zebrafish. |
| 源URL | [https://ir.rcees.ac.cn/handle/311016/47709]  |
| 专题 | 生态环境研究中心_环境水质学国家重点实验室 |
| 通讯作者 | Li, Li |
| 作者单位 | 1.Harbin Inst Technol, Sch Life Sci & Technol, Harbin 150080, Peoples R China 2.Harbin Inst Technol, Sch Phys, Harbin 150080, Peoples R China 3.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Aquat Chem, Beijing 100085, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 5.Wuyi Univ, Sch Biotechnol & Hlth Sci, Jiangmen 529020, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Xueting,Chen, Ce,He, Mingyue,et al. Lead Exposure Causes Spinal Curvature during Embryonic Development in Zebrafish[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2022,23(17):9571. |
| APA | Li, Xueting.,Chen, Ce.,He, Mingyue.,Yu, Lidong.,Liu, Renhao.,...&Li, Li.(2022).Lead Exposure Causes Spinal Curvature during Embryonic Development in Zebrafish.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,23(17),9571. |
| MLA | Li, Xueting,et al."Lead Exposure Causes Spinal Curvature during Embryonic Development in Zebrafish".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 23.17(2022):9571. |
入库方式： OAI收割
来源：生态环境研究中心
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