A SPE-HPLC-MS/MS method for the simultaneous determination of prioritised pharmaceuticals and EDCs with high environmental risk potential in freshwater
文献类型：期刊论文
| 作者 | Li, Yuan; Taggart, Mark A.; McKenzie, Craig; Zhang, Zulin; Lu, Yonglong; Pap, Sabolc; Gibb, Stuart W. |
| 刊名 | JOURNAL OF ENVIRONMENTAL SCIENCES
 |
| 出版日期 | 2021-02 |
| 卷号 | 100页码:18-27 |
| 关键词 | Pharmaceuticals prioritisation Risk assessment trace level determination Water quality |
| ISSN号 | 1001-0742 |
| 英文摘要 | This work describes the development, optimisation and validation of an analytical method for the rapid determination of 17 priority pharmaceutical compounds and endocrine disrupting chemicals (EDCs). Rather than studying compounds from the same therapeutic class, the analyses aimed to determine target compounds with the highest risk potential (with particular regard to Scotland), providing a tool for further monitoring in different water matrices. Prioritisation was based on a systematic environmental risk assessment approach, using consumption data; wastewater treatment removal efficiency; environmental occurrence; toxicological effects; and pre-existing regulatory indicators. This process highlighted 17 compounds across various therapeutic classes, which were then quantified, at environmentally relevant concentrations, by a single analytical methodology. Analytical determination was achieved using a single-step solid phase extraction (SPE) procedure followed by high-performance liquid chromatography with tandem mass spectrometry (HPLC-MS/MS). The fully optimised method performed well for the majority of target compounds, with recoveries >71% for 15 of 17 analytes. The limits of quantification for most target analytes (14 of 17) ranged from 0.07 ng/L to 1.88 ng/L in river waters. The utility of this method was then demonstrated using real water samples associated with a rural hospital/setting. Eight compounds were targeted and detected, with the highest levels found for the analgesic, paracetamol (at up to 105,910 ng/L in the hospital discharge). This method offers a robust tool to monitor high priority pharmaceutical and EDC levels in various aqueous sample matrices. (C) 2020 The Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences. Published by Elsevier B.V. |
| WOS研究方向 | Environmental Sciences |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/45399]  |
| 专题 | 生态环境研究中心_城市与区域生态国家重点实验室 |
| 作者单位 | 1.Univ Highlands & Isl, Environm Res Inst, North Highland Coll, Castle St, Thurso KW14 7JD, Caithness, Scotland 2.Ctr Anat & Human Identificat, Forens Drug Res Grp, Sch Sci & Engn, Dundee, Scotland 3.James Hutton Inst, Environm & Biochem Sci Grp, Aberdeen AB15 8QH, Scotland 4.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, Beijing 100085, Peoples R China 5.Univ Novi Sad, Fac Tech Sci, Dept Environm Engn & Occupat Safety & Hlth, Novi Sad 21000, Serbia |
| 推荐引用方式 GB/T 7714 | Li, Yuan,Taggart, Mark A.,McKenzie, Craig,et al. A SPE-HPLC-MS/MS method for the simultaneous determination of prioritised pharmaceuticals and EDCs with high environmental risk potential in freshwater[J]. JOURNAL OF ENVIRONMENTAL SCIENCES,2021,100:18-27. |
| APA | Li, Yuan.,Taggart, Mark A..,McKenzie, Craig.,Zhang, Zulin.,Lu, Yonglong.,...&Gibb, Stuart W..(2021).A SPE-HPLC-MS/MS method for the simultaneous determination of prioritised pharmaceuticals and EDCs with high environmental risk potential in freshwater.JOURNAL OF ENVIRONMENTAL SCIENCES,100,18-27. |
| MLA | Li, Yuan,et al."A SPE-HPLC-MS/MS method for the simultaneous determination of prioritised pharmaceuticals and EDCs with high environmental risk potential in freshwater".JOURNAL OF ENVIRONMENTAL SCIENCES 100(2021):18-27. |
入库方式： OAI收割
来源：生态环境研究中心
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