Mercury accumulation response of rice plant (Oryza sativa L.) to elevated atmospheric mercury and carbon dioxide
文献类型：期刊论文
| 作者 | Tang, Bin; Chen, Jian; Wang, Zhangwei; Qin, Pufeng; Zhang, Xiaoshan |
| 刊名 | ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
 |
| 出版日期 | 2021 |
| 卷号 | 420页码:- |
| 关键词 | PBDEs Quinone EPR ROS Neurotoxicity |
| ISSN号 | 0304-3894 |
| 英文摘要 | Polybrominated diphenyl ethers (PBDEs) are a category of brominated flame retardants, which were widely used in industrial products since the 1970 s. Our previous studies indicated quinone-type metabolites of PBDEs (PBDE-Qs) cause neurotoxicity, however, their inherent toxicological mechanism remains unclear. Here, we first synthesized PBDE-Qs and corresponding reduced hydroquinone homologous (PBDE-HQs) with different pattern of bromine substitution. Their nucleophilic and redox properties were investigated. PBDE-Qs react with reduced glutathione (GSH) via Michael addition and bromine displacement reaction, whilst PBDE-HQs lack the ability of reacting with GSH. Of note, the displacement reaction only occurs with bromine on the quinone ring of PBDE-Qs but not phenyl ring. Next, electron paramagnetic resonance (EPR) analysis revealed the generation of SQ(center dot-) , along with their downstream hydroxyl radical (HO') and methyl radical ((CH3)-C-center dot) through a PBDE quinone/semiquinone/hydroquinone (Q/SQ(center dot-)/HQ) futile cycle. In addition, a structure-dependent cytotoxicity pattern was found, the exposure of PBDE-Q/HQ with bromine substitution on the quinone ring resulted in higher level of apoptosis and autophagy in BV2 cells. In conclusion, this work clearly demonstrated that the nucleophilic and redox properties of PBDE-Qs/HQs are responsible for their neurotoxicity, and this finding provide better understanding of neurotoxicity of PBDEs. |
| 源URL | [https://ir.rcees.ac.cn/handle/311016/46743]  |
| 专题 | 生态环境研究中心_城市与区域生态国家重点实验室 |
| 作者单位 | 1.Hunan Res Acad Environm Sci, Hunan Prov Key Lab Water Pollut Control Technol, Changsha 410002, Peoples R China 2.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Urban & Reg Ecol, Beijing 100085, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Hunan Agr Univ, Coll Resources & Environm, Changsha 410128, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tang, Bin,Chen, Jian,Wang, Zhangwei,et al. Mercury accumulation response of rice plant (Oryza sativa L.) to elevated atmospheric mercury and carbon dioxide[J]. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,2021,420:-. |
| APA | Tang, Bin,Chen, Jian,Wang, Zhangwei,Qin, Pufeng,&Zhang, Xiaoshan.(2021).Mercury accumulation response of rice plant (Oryza sativa L.) to elevated atmospheric mercury and carbon dioxide.ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,420,-. |
| MLA | Tang, Bin,et al."Mercury accumulation response of rice plant (Oryza sativa L.) to elevated atmospheric mercury and carbon dioxide".ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY 420(2021):-. |
入库方式： OAI收割
来源：生态环境研究中心
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