Spatiotemporal variability of water ecosystem services can be effectively quantified by a composite indicator approach
文献类型：期刊论文
| 作者 | Lu, Da; Lu, Yihe |
| 刊名 | ECOLOGICAL INDICATORS
 |
| 出版日期 | 2021 |
| 卷号 | 224页码:- |
| ISSN号 | 0147-6513 |
| 关键词 | PM2.5 Carbon black Cd BEAS-2B cells Apoptosis |
| 英文摘要 | Particulate matter 2.5 (PM2.5) has adverse biological effects on major living organs in the body, including lungs. The complex composition of PM2.5, including carbon black and heavy metals, cause toxic effects to the lung. Nonetheless, there exists considerable knowledge gaps regarding the impact of carbon black (CB) on environmental health and safety (EHS). Thus far, the synergistic effects of CB have not gained much attention in past decades. Here, we showed that combined exposure of CB and Cadmium (Cd) enhance the cytotoxicity by altering the state of cell membrane. Specially, CB caused cell membrane collapse and increased the permeability of cells, and remarkedly enhanced the metal Cd toxicity. Furthermore, upon pre-treatment sublethal-dose CB, the increased intracellular Cd brought about a significantly amount of lactate dehydrogenase (LDH) and high expression of metallothionein-1 (MT-1) in human lung epithelial cell line (BEAS-2B) cells, and ultimately resulted an increased cellular toxicity. The lung of mice exposed CBs and Cd presented remarkably inflammation than Cd alone. Mechanistic exploration deciphered that CB pre-treatment triggered cell damage via apoptosis due to Cd exposure. Collectively, our findings reveal a novel path for understanding the impact of CB on EHS with its synergistic effects, through which nanomaterials might exert detrimental effects on organisms. |
| 源URL | [https://ir.rcees.ac.cn/handle/311016/46762]  |
| 专题 | 生态环境研究中心_城市与区域生态国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Urban & Reg Ecol, POB 2871, Beijing 100085, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lu, Da,Lu, Yihe. Spatiotemporal variability of water ecosystem services can be effectively quantified by a composite indicator approach[J]. ECOLOGICAL INDICATORS,2021,224:-. |
| APA | Lu, Da,&Lu, Yihe.(2021).Spatiotemporal variability of water ecosystem services can be effectively quantified by a composite indicator approach.ECOLOGICAL INDICATORS,224,-. |
| MLA | Lu, Da,et al."Spatiotemporal variability of water ecosystem services can be effectively quantified by a composite indicator approach".ECOLOGICAL INDICATORS 224(2021):-. |
入库方式： OAI收割
来源：生态环境研究中心
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