Combined pollution of arsenic and Polymyxin B enhanced arsenic toxicity and enriched ARG abundance in soil and earthworm gut microbiotas
文献类型：期刊论文
| 作者 | Li, Lyu; Zhu, Dong; Yi, Xingyun; Su, Jianqiang; Duan, Guilan ; Tang, Xianjin; Zhu, Yongguan
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| 刊名 | JOURNAL OF ENVIRONMENTAL SCIENCES
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| 出版日期 | 2021 |
| 卷号 | 109期号:0页码:170-181 |
| 关键词 | Arsenic Soil Earthworm gut microbiotas Polymyxin B Antibiotic resistance genes |
| 英文摘要 | A B S T R A C T Polymyxin B (PMB) is considered as the last line of antibiotic defense available to humans. The environmental effects of the combined pollution with PMB and heavy metals and their interaction mechanisms are unclear. We explored the effects of the combined pollution with PMB and arsenic (As) on the microbial composition of the soil and in the earthworm gut, as well as the spread and transmission of antibiotic resistance genes (ARGs). The results showed that, compared with As alone, the combined addition of PMB and As could significantly increase the bioaccumulation factor and toxicity of As in earthworm tissues by 12.1% and 16.0%, respectively. PMB treatment could significantly increase the abundance of Actinobacteria in the earthworm gut (from 35.6% to 45.2%), and As stress could significantly increase the abundance of Proteobacteria (from 19.8% to 56.9%). PMB and As stress both could significantly increase the abundance of ARGs and mobile genetic elements (MGEs), which were positively correlated, indicating that ARGs might be horizontally transferred. The inactivation of antibiotics was the main resistance mechanism that microbes use to resist PMB and As stress. Network analysis showed that PMB and As might have antagonistic effects through competition with multi-drug resistant ARGs. The combined pollution by PMB and As significantly promoted the relative abundance of microbes carrying multi-drug resistant ARGs and MGEs, thereby increasing the risk of transmission of ARGs. This research advances the understanding of the interaction mechanism between antibiotics and heavy metals and provides new theoretical guidance for the environmental risk assessment and combined pollution management. (c) 2021 The Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences. Published by Elsevier B.V. |
| 源URL | [https://ir.rcees.ac.cn/handle/311016/46928]  |
| 专题 | 生态环境研究中心_城市与区域生态国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Urban & Reg Ecol, Beijing 100085, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Inst Urban Environm, Key Lab Urban Environm & Hlth, Xiamen 361021, Peoples R China 4.Zhejiang Univ, Inst Soil & Water Resources & Environm Sci, Hangzhou 310058, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Lyu,Zhu, Dong,Yi, Xingyun,et al. Combined pollution of arsenic and Polymyxin B enhanced arsenic toxicity and enriched ARG abundance in soil and earthworm gut microbiotas[J]. JOURNAL OF ENVIRONMENTAL SCIENCES,2021,109(0):170-181. |
| APA | Li, Lyu.,Zhu, Dong.,Yi, Xingyun.,Su, Jianqiang.,Duan, Guilan.,...&Zhu, Yongguan.(2021).Combined pollution of arsenic and Polymyxin B enhanced arsenic toxicity and enriched ARG abundance in soil and earthworm gut microbiotas.JOURNAL OF ENVIRONMENTAL SCIENCES,109(0),170-181. |
| MLA | Li, Lyu,et al."Combined pollution of arsenic and Polymyxin B enhanced arsenic toxicity and enriched ARG abundance in soil and earthworm gut microbiotas".JOURNAL OF ENVIRONMENTAL SCIENCES 109.0(2021):170-181. |
入库方式： OAI收割
来源：生态环境研究中心
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