Serum concentrations of per-/polyfluoroalkyl substances and its association with renal function parameters among teenagers near a Chinese fluorochemical industrial plant: A cross-sectional study
文献类型：期刊论文
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| 作者 | Xie, Lin-Na; Wang, Xiao-Chen; Su, Li-Qin; Ji, Sai-Sai; Dong, Xiao-Jie; Zhu, Hui-Juan; Hou, Sha-Sha; Wang, Cong; Li, Zhen-Huan; Dong, Bing |
| 刊名 | ENVIRONMENTAL POLLUTION
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| 出版日期 | 2022-06-01 |
| 卷号 | 302期号:0页码:119020 |
| ISSN号 | 0269-7491 |
| 关键词 | CHRONIC KIDNEY-DISEASE PERFLUOROOCTANOIC ACID PFOA C8 HEALTH PROJECT BODY-MASS INDEX PERFLUOROALKYL ACIDS HUMAN EXPOSURE CREATININE RATIO BIRTH-WEIGHT PARK BIOACCUMULATION |
| 英文摘要 | Currently, studies on the association between per-/polyfluoroalkyl substances (PFAS) concentrations and the renal function of residents, especially teenagers, living near fluorochemical industrial plants, are relatively rare, and not all these studies suggested associations. In this cross-sectional study, 775 local teenagers (11-15 years old) were included, and serum concentrations of 18 PFAS were measured. Perfluorooctanoic acid (PFOA) was found to be the dominant PFAS with a concentration of 22.3-3310 ng/mL (mean = 191 ng/mL), accounting for 71.5-99.1% of sigma PFAS. Statistical analyses demonstrated that internal exposure of perfluoroalkyl carboxylic acids (PFCA, C8-C10) was related to the plant. In addition, the prevalence rate of chronic kidney disease (CKD) (35.0%) in the participants was relatively high. A significantly positive association was observed between the increase in PFOA concentration and increasing risk of CKD (OR = 1.741; 95% CI: 1.004, 3.088; p = 0.048) by adjusting for gender, age, body mass index (BMI), and household income. Similar positive correlation was also observed in PFHpA with CKD (OR =1.628, 95% CI: 1.031, 2.572; p = 0.037). However, no significant correlation was observed for concentrations of other PFAS and CKD (p > 0.05). Furthermore, linear regression analyses demonstrated that none of the PFAS concentrations were significantly correlated with estimated glomerular filtration rate (eGFR) or urine albumin/urine creatinine ratio (ACR) (p > 0.05). However, a significantly negative correlation was observed between PFOA concentration and abnormal ACR (beta =-0.141, 95% CI:-0.283, 0.001; p = 0.048) after stratifying by CKD. Sensitivity analyses further confirmed these results. This cross-sectional study is the first, to our knowledge, to investigate the association between PFAS concentrations and renal function in teenagers living near a Chinese industrial plant. Further prospective and metabonomic studies are needed to interpret the results and clarify the biological mechanisms underlying this association. |
| 源URL | [https://ir.rcees.ac.cn/handle/311016/47330]  |
| 专题 | 生态环境研究中心_城市与区域生态国家重点实验室 |
| 通讯作者 | Zhu, Ying |
| 作者单位 | 1.Natl Inst Environm Hlth, Chinese Ctr Dis Control & Prevent, China CDC Key Lab Environm & Populat Hlth, Beijing 100021, Peoples R China 2.Res Ctr Ecoenvironm Sci, Chinese Acad Sci, State Key Lab Urban & Reg Ecol, Beijing 100085, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xie, Lin-Na,Wang, Xiao-Chen,Su, Li-Qin,et al. Serum concentrations of per-/polyfluoroalkyl substances and its association with renal function parameters among teenagers near a Chinese fluorochemical industrial plant: A cross-sectional study, Serum concentrations of per-_polyfluoroalkyl substances and its association with renal function parameters among teenagers near a Chinese fluorochemical industrial plant_ A cross-sectional study.pdf[J]. ENVIRONMENTAL POLLUTION,2022,302(0):119020. |
| APA | Xie, Lin-Na.,Wang, Xiao-Chen.,Su, Li-Qin.,Ji, Sai-Sai.,Dong, Xiao-Jie.,...&Zhu, Ying.(2022).Serum concentrations of per-/polyfluoroalkyl substances and its association with renal function parameters among teenagers near a Chinese fluorochemical industrial plant: A cross-sectional study.ENVIRONMENTAL POLLUTION,302(0),119020. |
| MLA | Xie, Lin-Na,et al."Serum concentrations of per-/polyfluoroalkyl substances and its association with renal function parameters among teenagers near a Chinese fluorochemical industrial plant: A cross-sectional study".ENVIRONMENTAL POLLUTION 302.0(2022):119020. |
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来源：生态环境研究中心
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