Multi-omics analysis reveals copper-induced growth inhibition mechanisms of earthworm (Eisenia fetida)
文献类型：期刊论文
| 作者 | Zhang, Yanliang; Zhao, Jinqi; Sa, Na; Huang, Chenyu; Yu, Wenyu; Ma, Tianxiao; Yang, Hongjun; Ma, Fang ; Sun, Siqi; Tang, Chaochun
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| 刊名 | ENVIRONMENTAL POLLUTION
 |
| 出版日期 | 2023 |
| 卷号 | 318页码:120862-1-12 |
| 关键词 | Earthworm Copper Transcriptomics Metabolomics Gut microbiota Growth inhibition |
| ISSN号 | 0269-7491 |
| 英文摘要 | Exposure to high concentrations of copper can cause toxic effects on the growth and development of organisms, but the relevant toxic mechanisms are far from fully understood. This study investigated the changes of me-tabolites, genes, and gut microorganisms in earthworms (Eisenia fetida) exposed to 0 (control), 67.58 (low), 168.96 (medium), and 337.92 (high) mg/kg of Cu in soil for 60 days. Differentially expressed genes (DEGs) and differential metabolites (DMs) at the low-, medium-, and high-level Cu exposure groups were identified and introduced into Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways. Integrated metabolomic and transcriptomic analysis revealed that amino acid metabolism, lipid metabolism, and carbohydrate metabolism are the major metabolic pathways disturbed by Cu exposure. Furthermore, Cu exposure significantly decreased the diversity of the intestinal bacterial community and affected the relative abundance (increased or decreased) of intestinal colonizing bacteria. This resulted in high energy expenditure, inhibited nutrient absorption and fatty acid synthesis, and weakened antioxidant and detoxification abilities, ultimately inhibiting the growth of E. fetida. These findings offer important clues and evidence for understanding the mechanism of Cu-induced growth and development toxicity in E. fetida and provide further data for risk assessment in terrestrial ecosystems. |
| 源URL | [https://ir.rcees.ac.cn/handle/311016/48420]  |
| 专题 | 生态环境研究中心_城市与区域生态国家重点实验室 |
| 作者单位 | 1.Binzhou University 2.Chinese Academy of Sciences 3.Research Center for Eco-Environmental Sciences (RCEES) 4.University of Chinese Academy of Sciences, CAS |
| 推荐引用方式 GB/T 7714 | Zhang, Yanliang,Zhao, Jinqi,Sa, Na,et al. Multi-omics analysis reveals copper-induced growth inhibition mechanisms of earthworm (Eisenia fetida)[J]. ENVIRONMENTAL POLLUTION,2023,318:120862-1-12. |
| APA | Zhang, Yanliang.,Zhao, Jinqi.,Sa, Na.,Huang, Chenyu.,Yu, Wenyu.,...&Sang, Weiguo.(2023).Multi-omics analysis reveals copper-induced growth inhibition mechanisms of earthworm (Eisenia fetida).ENVIRONMENTAL POLLUTION,318,120862-1-12. |
| MLA | Zhang, Yanliang,et al."Multi-omics analysis reveals copper-induced growth inhibition mechanisms of earthworm (Eisenia fetida)".ENVIRONMENTAL POLLUTION 318(2023):120862-1-12. |
入库方式： OAI收割
来源：生态环境研究中心
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