Alteration of intestinal microecology by oral antibiotics promotes oral squamous cell carcinoma development
文献类型：期刊论文
| 作者 | Wei, Wei ; Li, Jia; Liu, Fan; Wu, Miaomiao; Xiong, Kaixin; He, Qing; Zhang, Bo; Deng, Ye; Li, Yan
|
| 刊名 | MOLECULAR IMMUNOLOGY
 |
| 出版日期 | 2022-09-01 |
| 卷号 | 149期号:0页码:94-106 |
| ISSN号 | 0161-5890 |
| 关键词 | CANCER TYROSINE METABOLISM OPPORTUNITIES NECROPTOSIS MICROBIOME DISEASE VACCINE HEAD |
| 英文摘要 | Oral antibiotics can influence cancers and immunotherapy by interfering with the intestinal microbiota. How-ever, the association between oral antibiotics and oral squamous cell carcinoma (OSCC) as well as the mecha-nisms underlying the effects of oral antibiotics on OSCC remain unclear. Here, we found that oral antibiotics cocktail (4Abx) promoted the tumor development and shifted the microbiota, decreasing the abundance of probiotic bacteria, and altered microbial metabolism in the gut of OSCC mice, increasing tyrosine and decreasing glutamate levels. In vitro experiments showed that tyrosine upregulated the PD-1 expression in T cells, SCC7 cell proliferation, and necroptosis expression. IL-10 expression level in CD11c+ cells was reduced by glutamate. Furthermore, the expression of the necroptosis-related proteins, including receptor-interacting protein kinase 1 (RIPK1), RIPK3, and mixed lineage kinase domain-like (MLKL), was higher in the OSCC mice treated with 4Abx. Supplementation with glutamate or healthy mouse feces by gavage alleviated the tumor-promoting effect of 4Abx with restored balance of microbial metabolism. Overall, we identified the detrimental role of oral anti-biotics in promoting OSCC development through altered intestinal microbiota, microbial metabolism, and im-mune dysbiosis, implying the need for antibiotic stewardship in OSCC treatment. |
| 源URL | [https://ir.rcees.ac.cn/handle/311016/47768]  |
| 专题 | 生态环境研究中心_中国科学院环境生物技术重点实验室 |
| 通讯作者 | Li, Yan |
| 作者单位 | 1.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, CAS Key Lab Environm Biotechnol, Beijing 100085, Peoples R China 2.Sichuan Univ, West China Hosp Stomatol, Natl Clin Res Ctr Oral Dis, State Key Lab Oral Dis, Chengdu 610041, Peoples R China 3.Hubei Minzu Univ, Dept Stomatol, Minda Hosp, Enshi 445000, Peoples R China 4.Sichuan Univ, West China Hosp Stomatol, Nursing Dept, Chengdu 610041, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wei, Wei,Li, Jia,Liu, Fan,et al. Alteration of intestinal microecology by oral antibiotics promotes oral squamous cell carcinoma development[J]. MOLECULAR IMMUNOLOGY,2022,149(0):94-106. |
| APA | Wei, Wei.,Li, Jia.,Liu, Fan.,Wu, Miaomiao.,Xiong, Kaixin.,...&Li, Yan.(2022).Alteration of intestinal microecology by oral antibiotics promotes oral squamous cell carcinoma development.MOLECULAR IMMUNOLOGY,149(0),94-106. |
| MLA | Wei, Wei,et al."Alteration of intestinal microecology by oral antibiotics promotes oral squamous cell carcinoma development".MOLECULAR IMMUNOLOGY 149.0(2022):94-106. |
入库方式： OAI收割
来源：生态环境研究中心
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