Microplastics boost the accumulation of tetrabromobisphenol A in a commercial clam and elevate corresponding food safety risks
文献类型：期刊论文
| 作者 | Zhang, Weixia; Tang, Yu; Han, Yu; Zhou, Weishang; Shi, Wei ; Teng, Shuangshuang; Ren, Peng; Xiao, Guoqiang; Li, Shiguo; Liu, Guangxu
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| 刊名 | CHEMOSPHERE
 |
| 出版日期 | 2022-04 |
| 卷号 | 292期号:0页码:133499 |
| 关键词 | BROMINATED FLAME RETARDANTS PYRUVATE-KINASE M2 DETOXIFICATION RESPONSES MARINE-SEDIMENTS OXIDATIVE STRESS MYTILUS-EDULIS P-GLYCOPROTEIN TBBPA EXPOSURE BIOACCUMULATION |
| ISSN号 | 0045-6535 |
| 英文摘要 | Marine bivalve molluscs are one of the primary seafood for consumers. Inhabiting terrigenous pollutant-convergent coastal areas and feeding through seawater filtration, edible bivalves are subjected to waterborne emerging pollutants such as microplastics (MPs) and tetrabromobisphenol A (TBBPA). Nevertheless, the potential risks of consuming MP-TBBPA contaminated seafood are still largely unknown. With that, accumulation of TBBPA with and without the presence of MPs in a commercial bivalve species, blood clam (Tegillarca granosa), was determined in the present study. Meanwhile, corresponding target hazard quotients (THQs) as well as margins of exposure (MoEs) were estimated to evaluate the potential health risks for clam consumers. Furthermore, the impacts of pollutants accumulation on the detoxification process and energy supply were analysed. The data obtained demonstrated that MPs aggravate the accumulation of TBBPA in clams, leading to elevated potential food safety risks (indicated by higher THQ values and lower MoE values) for consumers. In addition, the in vivo contents of CYP1A1 and UDP-glucuronosyltransferase, the enzymatic activity of glutathione-S-transferase, and the expression levels of five detoxification-related genes were all dramatically suppressed by MP-TBBPA. Furthermore, clams exposed to MP-TBBPA had significantly lower adenosine triphosphate contents and lower pyruvate kinase and phosphofructokinase activities. These results indicated that the aggravation of TBBPA accumulation may be due to the hence disruption of detoxification process and limited energy available for detoxification. |
| 源URL | [https://ir.rcees.ac.cn/handle/311016/47801]  |
| 专题 | 生态环境研究中心_中国科学院环境生物技术重点实验室 |
| 通讯作者 | Liu, Guangxu |
| 作者单位 | 1.Zhejiang Mariculture Res Inst, Wenzhou 325005, Peoples R China 2.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, Key Lab Environm Biotechnol, Beijing 100085, Peoples R China 3.Zhejiang Univ, Coll Anim Sci, 866 Yuhangtang Rd, Hangzhou 310058, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Weixia,Tang, Yu,Han, Yu,et al. Microplastics boost the accumulation of tetrabromobisphenol A in a commercial clam and elevate corresponding food safety risks[J]. CHEMOSPHERE,2022,292(0):133499. |
| APA | Zhang, Weixia.,Tang, Yu.,Han, Yu.,Zhou, Weishang.,Shi, Wei.,...&Liu, Guangxu.(2022).Microplastics boost the accumulation of tetrabromobisphenol A in a commercial clam and elevate corresponding food safety risks.CHEMOSPHERE,292(0),133499. |
| MLA | Zhang, Weixia,et al."Microplastics boost the accumulation of tetrabromobisphenol A in a commercial clam and elevate corresponding food safety risks".CHEMOSPHERE 292.0(2022):133499. |
入库方式： OAI收割
来源：生态环境研究中心
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