Toxicological effects of acute prothioconazole and prothioconazole-desthio administration on liver in male Chinese lizards (Eremias argus)
文献类型：期刊论文
| 作者 | Xie, Yun; Chang, Jing ; Pan, Yifan; Hao, Weiyu; Li, Jianzhong
|
| 刊名 | CHEMOSPHERE
 |
| 出版日期 | 2022-03 |
| 卷号 | 291期号:0页码:132825 |
| 关键词 | OXIDATIVE STRESS TISSUE DISTRIBUTION HEPATOTOXICITY TOXICOKINETICS METABOLISM EXPRESSION APOPTOSIS DEATH PART MICE |
| ISSN号 | 0045-6535 |
| 英文摘要 | Prothioconazole (PTC) is a high effective systemic fungicide, and one of its major metabolites is prothioconazoledesthio (PTC-d). Because of its wildly use in the farmland of China, the local eco-toxicological effects of PTC as well as PTC-d are needed to be concerned. This study investigated hepatoxicity of Chinese lizards (Eremias argus), a local non-target organism, after single dose oral treated (100 mg kg(-1) BW) through pathological, enzyme activity and gene expression analysis. PTC treatment caused ballooning and PTC-d treatment led to macro vesicular steatosis of hepatocyte. The elevation of serum indexes, including the activities of aspartate aminotransferase (AST), alkaline phosphatase (ALP) and alanine aminotransferase (ALT), further confirmed the hepatic injury. PTC and PTC-d treatments altered oxidative status reflected by the inhibition of superoxide dismutase (SOD) activity , meanwhile, the stimulation of catalase (CAT) activity, glutathione peroxidase (GPx) activity and malondialdehyde (MDA) content. The mRNA expression changes of apoptosis-related factors and cytokines genes, including Bax, Bcl-2, TNF-alpha, NF-kappa B, Caspase-3 and Nrf2, deeply uncovered the potential mechanism of hepatotoxicity caused by PTC and PTC-d. In brief, the results indicated that both of these two compounds altered oxidative status, then were likely to trigger caspase-3 by affecting the ratio of pro-and anti-apoptotic factors which belong to intrinsic apoptosis pathway. Specifically, more serious impacts were induced by PTC-d than its parent compound. This study is the first to provide specific insight into potential hepatotoxicity resulted from PTC and PTC-d in male Chinese lizards. |
| 源URL | [https://ir.rcees.ac.cn/handle/311016/47825]  |
| 专题 | 生态环境研究中心_中国科学院环境生物技术重点实验室 |
| 通讯作者 | Xie, Yun |
| 作者单位 | 1.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, Shuangqing RD 18, Beijing 100085, Peoples R China 2.Chinese Acad Inspect & Quarantine, Inst Food Safety, Beijing 100176, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xie, Yun,Chang, Jing,Pan, Yifan,et al. Toxicological effects of acute prothioconazole and prothioconazole-desthio administration on liver in male Chinese lizards (Eremias argus)[J]. CHEMOSPHERE,2022,291(0):132825. |
| APA | Xie, Yun,Chang, Jing,Pan, Yifan,Hao, Weiyu,&Li, Jianzhong.(2022).Toxicological effects of acute prothioconazole and prothioconazole-desthio administration on liver in male Chinese lizards (Eremias argus).CHEMOSPHERE,291(0),132825. |
| MLA | Xie, Yun,et al."Toxicological effects of acute prothioconazole and prothioconazole-desthio administration on liver in male Chinese lizards (Eremias argus)".CHEMOSPHERE 291.0(2022):132825. |
入库方式： OAI收割
来源：生态环境研究中心
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