Profiles of antibiotic resistome and microbial community in groundwater of CKDu prevalence zones in Sri Lanka
文献类型：期刊论文
| 作者 | Cooray, Titus; Zhang, Junya ; Zhong, Hui; Zheng, Libing; Wei, Yuansong; Weragoda, Sujithra K.; Jinadasa, K. B. S. N.; Weerasooriya, Rohan
|
| 刊名 | JOURNAL OF HAZARDOUS MATERIALS
 |
| 出版日期 | 2021-02-05 |
| 卷号 | 403页码:- |
| 关键词 | Chronic kidney disease of unknown etiology Groundwater Antibiotic resistome Microbial community Sri Lanka |
| ISSN号 | 0304-3894 |
| 英文摘要 | The chronic kidney disease of unknown etiology (CKDu) prevalent in certain regions of Sri Lanka poses a serious threat to human health. Previous epidemiological studies focused on the search of causative agents for CKDu etiology from the viewpoint of groundwater composition, but how CKDu prevalence affected the groundwater microbial composition, especially the antibiotic resistome, has never been illuminated. This study investigated the response of microbial community and antibiotic resistome to CKDu prevalence in the groundwater through the high throughput sequencing and qPCR (HT-qPCR), respectively. Results showed that CKDu prevalence significantly influenced the distribution of antibiotic resistome and microbial community composition. The mexF dominated in all the groundwater samples and could be considered as an intrinsic ARG, and the beta-lactamase cphA was specially enriched and closely associated with the antibiotics used for CKDu patients. The Acinetobacter was a potential human pathogen common in the groundwater of CKDu affected regions, while CKDu prevalence specially enriched the Aeromonas. Statistical analysis indicated that CKDu prevalence impacted antibiotic resistome through the microbial community as a whole, and MGEs contributed to the occurrence of mexF, while the enrichment of cphA could be attributed to the increase of Aeromonas. |
| WOS研究方向 | Engineering, Environmental ; Environmental Sciences |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/46063]  |
| 专题 | 生态环境研究中心_水污染控制实验室 |
| 作者单位 | 1.Chinese Acad Sci, State Key Joint Lab Environm Simulat & Pollut Con, Res Ctr Ecoenvironm Sci, Beijing 100085, Peoples R China 2.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, Dept Water Pollut Control Technol, Beijing 100085, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Uva Wellassa Univ, Dept Appl Earth Sci, Badulla 90000, Sri Lanka 5.Natl Water Supply & Drainage Board, Katugastota 20800, Sri Lanka 6.Univ Peradeniya, Fac Engn, Dept Civil Engn, Peradeniya 20400, Sri Lanka |
| 推荐引用方式 GB/T 7714 | Cooray, Titus,Zhang, Junya,Zhong, Hui,et al. Profiles of antibiotic resistome and microbial community in groundwater of CKDu prevalence zones in Sri Lanka[J]. JOURNAL OF HAZARDOUS MATERIALS,2021,403:-. |
| APA | Cooray, Titus.,Zhang, Junya.,Zhong, Hui.,Zheng, Libing.,Wei, Yuansong.,...&Weerasooriya, Rohan.(2021).Profiles of antibiotic resistome and microbial community in groundwater of CKDu prevalence zones in Sri Lanka.JOURNAL OF HAZARDOUS MATERIALS,403,-. |
| MLA | Cooray, Titus,et al."Profiles of antibiotic resistome and microbial community in groundwater of CKDu prevalence zones in Sri Lanka".JOURNAL OF HAZARDOUS MATERIALS 403(2021):-. |
入库方式： OAI收割
来源：生态环境研究中心
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。