Metagenomics insights into the profiles of antibiotic resistome in combined sewage overflows from reads to metagenome assembly genomes
文献类型：期刊论文
| 作者 | Zhang, Junya ; Yu, Dawei; Dian, Liu; Hai, Yonglong; Xin, Yuan; Wei, Yuansong
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| 刊名 | JOURNAL OF HAZARDOUS MATERIALS
 |
| 出版日期 | 2022-05-05 |
| 卷号 | 429期号:0页码:128277 |
| ISSN号 | 0304-3894 |
| 关键词 | RESISTANCE GENES DIVERSITY |
| 英文摘要 | Combined sewage overflows (CSOs) have become an important source of antibiotic resistance genes (ARGs) in the environment, while the distribution and dynamics of antibiotic resistome in the CSOs events have not been well understood. This study deciphered the profiles of antibiotic resitome in the CSOs based on metagenomics analysis from reads to metagenome assembly genomes (MAGs), and the dynamical changes of ARGs were clarified through continuous monitoring of the CSO event. Results showed that antibiotic inactivation was the dominant resistance mechanism, and sulfonamide, aminoglycoside along with multidrug resistance were the dominant antibiotic resistance types. It was speculated that the antibiotic resistome were generally determined by sewer sediment flushed out along with the CSOs not domestic sewage in the pipes. The host range and mobility of the antibiotic resistome were determined at contigs level, and the hosts mainly belonged to the Proteobacteria with the genus of Pseudomonas, Escherichia, Enterobacter and Aeromonas being dominant. The transposase (tnpA), 1591 and integmns were mobile genetic elements (MGEs) located together with ARGs, and a MAG carrying 32 ARGs and 140 VFGs was assembled. Although microbial community contributed most to the changes of antibiotic resistome in the CSOs directly, the risks caused by the MGEs should be paid more attention. |
| 源URL | [https://ir.rcees.ac.cn/handle/311016/47753]  |
| 专题 | 生态环境研究中心_水污染控制实验室 |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Joint Lab Environm Simulat & Pollut Con, Beijing 100085, Peoples R China 3.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, Lab Water Pollut Control Technol, Beijing 100085, Peoples R China 4.Guangxi Univ, Coll Life Sci & Technol, Nanning 530005, Guangxi, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Junya,Yu, Dawei,Dian, Liu,et al. Metagenomics insights into the profiles of antibiotic resistome in combined sewage overflows from reads to metagenome assembly genomes[J]. JOURNAL OF HAZARDOUS MATERIALS,2022,429(0):128277. |
| APA | Zhang, Junya,Yu, Dawei,Dian, Liu,Hai, Yonglong,Xin, Yuan,&Wei, Yuansong.(2022).Metagenomics insights into the profiles of antibiotic resistome in combined sewage overflows from reads to metagenome assembly genomes.JOURNAL OF HAZARDOUS MATERIALS,429(0),128277. |
| MLA | Zhang, Junya,et al."Metagenomics insights into the profiles of antibiotic resistome in combined sewage overflows from reads to metagenome assembly genomes".JOURNAL OF HAZARDOUS MATERIALS 429.0(2022):128277. |
入库方式： OAI收割
来源：生态环境研究中心
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