Predictive capabilities of in vitro colon bioaccessibility for estimating in vivo relative bioavailability of arsenic from contaminated soils: Arsenic speciation and gut microbiota considerations
文献类型：期刊论文
| 作者 | Yin, Naiyi; Cai, Xiaolin; Wang, Pengfei; Feng, Run; Du, Huili; Fu, Yaqi; Sun, Guoxin ; Cui, Yanshan
|
| 刊名 | SCIENCE OF THE TOTAL ENVIRONMENT
 |
| 出版日期 | 2022-04-20 |
| 卷号 | 818期号:0页码:151804 |
| ISSN号 | 0048-9697 |
| 关键词 | METABOLISM VALIDATION EXPOSURE VARIABILITY RELEVANT CADMIUM ASSAYS LEAD |
| 英文摘要 | Arsenic (As) transformation by human gut microbiota has been evidenced to impact As toxicity and human health. However, little is known about the influence of gut microbiota on As bioavailability from incidental ingestion of soil. In this study, we assessed As relative bioavailability (RBA) using an in vivo mouse model and As bioaccessibility in the colon phase of in vitro assays. Strong in vivo-in vitro correlations (R-2 = 0.70-0.92, P < 0.05) were observed between soil As RBA (10.2%-57.7%) and colon bioaccessibility (4.8%-49.0%) in 13 As-contaminated soils. Upon in vitro incubation of human colon microbiota, we found a high degree of As transformation and 65.9% of generated As(III) was observed in soil residues. For in vivo mouse assay. DMA(V) accounted for 79.0% of cumulative urinary As excretion. Except for As(V), dominant As species including As(III), DMA(V) and As sulfides were also detected in mouse feces. Gut bacteria (families Rikenellaceae and Marinifilaceae) could be significantly correlated with As intake and excretion in mice (P < 0.05). Our findings provide evidence that gut microbiota can affect transformation, bioavailability, and fate of the orally ingested soil As in human gastrointestinal tract. (C) 2021 Elsevier B.V. All rights reserved. |
| 源URL | [https://ir.rcees.ac.cn/handle/311016/47763]  |
| 专题 | 生态环境研究中心_土壤环境科学实验室 |
| 通讯作者 | Cui, Yanshan |
| 作者单位 | 1.Univ Chinese Acad Sci, Coll Resources & Environm, 380 Huaibeizhuang, Beijing 101408, Peoples R China 2.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, Beijing 100085, Peoples R China 3.Beijing Lab Anim Res Ctr BLARC, Beijing 100012, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yin, Naiyi,Cai, Xiaolin,Wang, Pengfei,et al. Predictive capabilities of in vitro colon bioaccessibility for estimating in vivo relative bioavailability of arsenic from contaminated soils: Arsenic speciation and gut microbiota considerations[J]. SCIENCE OF THE TOTAL ENVIRONMENT,2022,818(0):151804. |
| APA | Yin, Naiyi.,Cai, Xiaolin.,Wang, Pengfei.,Feng, Run.,Du, Huili.,...&Cui, Yanshan.(2022).Predictive capabilities of in vitro colon bioaccessibility for estimating in vivo relative bioavailability of arsenic from contaminated soils: Arsenic speciation and gut microbiota considerations.SCIENCE OF THE TOTAL ENVIRONMENT,818(0),151804. |
| MLA | Yin, Naiyi,et al."Predictive capabilities of in vitro colon bioaccessibility for estimating in vivo relative bioavailability of arsenic from contaminated soils: Arsenic speciation and gut microbiota considerations".SCIENCE OF THE TOTAL ENVIRONMENT 818.0(2022):151804. |
入库方式： OAI收割
来源：生态环境研究中心
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。