Inactivation of common airborne antigens by perfluoroalkyl chemicals modulates early life asthma
文献类型：期刊论文
| 作者 | Wang, Mengjing; Li, Qianqian; Hou, Meifang; Chan, Louisa L. Y.; Liu, Meng; Ter, Soo Kai; Dong, Ting; Xia, Yun; Chotirmall, Sanjay H.; Fang, Mingliang |
| 刊名 | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
 |
| 出版日期 | 2021-06-15 |
| 卷号 | 118期号:24页码:- |
| ISSN号 | 0027-8424 |
| 关键词 | early life exposure pulmonary immunomodulation house dust mites lipopolysaccharide perfluorinated chemicals |
| 英文摘要 | Allergic asthma, driven by T helper 2 cell-mediated immune responses to common environmental antigens, remains the most common respiratory disease in children. Perfluorinated chemicals (PFCs) are environmental contaminants of great concern, because of their wide application, persistence in the environment, and bioaccumulation. PFCs associate with immunological disorders including asthma and attenuate immune responses to vaccines. The influence of PFCs on the immunological response to allergens during childhood is unknown. We report here that a major PFC, perfluorooctane sulfonate (PFOS), inactivates house dust mite (HDM) to dampen 5-wk-old, early weaned mice from developing HDMinduced allergic asthma. PFOS further attenuates the asthma protective effect of the microbial product lipopolysaccharide (LPS). We demonstrate that PFOS prevents desensitization of lung epithelia by LPS, thus abolishing the latter's protective effect. A close mechanistic study reveals that PFOS specifically binds the major HDM allergen Der p1 with high affinity as well as the lipid A moiety of LPS, leading to the inactivation of both antigens. Moreover, PFOS at physiological human (nanomolar) concentrations inactivates Der p1 from HDM and LPS in vitro, although higher doses did not cause further inactivation because of possible formation of PFOS aggregates. This PFOS-induced neutralization of LPS has been further validated in primary human cell models and extended to an in vivo bacterial infection mouse model. This study demonstrates that early life exposure of mice to a PFC blunts airway antigen bioactivity to modulate pulmonary inflammatory responses, which may adversely affect early pulmonary health. |
| WOS研究方向 | Multidisciplinary Sciences |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/45889]  |
| 专题 | 生态环境研究中心_环境纳米材料实验室 |
| 作者单位 | 1.Nanyang Technol Univ, Lee Kong Chian Sch Med, Singapore 639798, Singapore 2.Shanghai Inst Technol, Sch Ecol Technol & Engn, Shanghai 201418, Peoples R China 3.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, Key Lab Environm Nanotechnol & Hlth Effects, Beijing 100085, Peoples R China 4.Nanyang Technol Univ, Sch Civil & Environm Engn, Singapore 639798, Singapore |
| 推荐引用方式 GB/T 7714 | Wang, Mengjing,Li, Qianqian,Hou, Meifang,et al. Inactivation of common airborne antigens by perfluoroalkyl chemicals modulates early life asthma[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2021,118(24):-. |
| APA | Wang, Mengjing.,Li, Qianqian.,Hou, Meifang.,Chan, Louisa L. Y..,Liu, Meng.,...&Fang, Mingliang.(2021).Inactivation of common airborne antigens by perfluoroalkyl chemicals modulates early life asthma.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,118(24),-. |
| MLA | Wang, Mengjing,et al."Inactivation of common airborne antigens by perfluoroalkyl chemicals modulates early life asthma".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 118.24(2021):-. |
入库方式： OAI收割
来源：生态环境研究中心
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