Automatic Ethylation-Purge and Trap-GC-ICP-MS for Methylmercury Analysis: Method Validation and Application for Isotope Dilution/Tracing
文献类型：期刊论文
| 作者 | Shen, Zelin; Zhang, Xiaoyan; Shi, Jianbo; Lv, Jungang; Liu, Guangliang; Hu, Ligang; Yin, Yongguang; Cai, Yong; Jiang, Guibin
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| 刊名 | ATOMIC SPECTROSCOPY
 |
| 出版日期 | 2021 |
| 卷号 | 287页码:- |
| 关键词 | Iron-bearing nanoparticles Particulate matter Endothelial cells Ferroptosis ROS |
| ISSN号 | 0269-7491 |
| 英文摘要 | Iron-bearing nanoparticles (IBNPs) were abundant in particulate matter (PM). Due to their high reactivity, IBNPs were considered hazardous to human health, however, their toxic mode-of-action(s) are highly unclear. Ferroptosis is a novel programmed cell death (PCD) that highly associated with intracellular iron. However, the proferroptotic effect of IBNPs has not been characterized. To this end, we ought to investigate whether and how IBNPs (synthetic gamma-Fe2O3 and Fe3O4 NPs were selected as the model compounds) are involved in ferroptosis. We found that human umbilical vein endothelial cells (HUVECs) phagocytized large qualities of gamma-Fe2O3 and Fe3O4 NPs, resulting in increased intracellular iron level. We further observed the disrupted cystine/glutamate reverse transporter (System X-c(-)) and glutathione peroxidase 4 (GPX4) signaling in gamma-Fe2O3 and Fe3O4 NPs-challenged HUVECs. gamma-Fe2O3 and Fe3O4 NPs could also cause mitochondrial fusion and fission dysregulation, activate lipid peroxidation and iron metabolism-related genes in a P53-dependent manner. Together, the ferroptotic activity of IBNPs should be acknowledged for the risk assessment of PM associated health effects. |
| 源URL | [https://ir.rcees.ac.cn/handle/311016/46831]  |
| 专题 | 生态环境研究中心_环境纳米材料实验室 |
| 作者单位 | 1.Univ Chinese Acad Sci UCAS, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, Lab Environm Nanotechnol & Hlth Effect, Beijing 100085, Peoples R China 3.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China 4.Supreme Peoples Procuratorate, Procuratoral Technol & Informat Res Ctr, Beijing 100040, Peoples R China 5.[Yin, Yongguang 6.UCAS, Hangzhou Inst Adv Study, Sch Environm, Hangzhou 310024, Peoples R China 7.Florida Int Univ, Dept Chem & Biochem, Miami, FL 33199 USA |
| 推荐引用方式 GB/T 7714 | Shen, Zelin,Zhang, Xiaoyan,Shi, Jianbo,et al. Automatic Ethylation-Purge and Trap-GC-ICP-MS for Methylmercury Analysis: Method Validation and Application for Isotope Dilution/Tracing[J]. ATOMIC SPECTROSCOPY,2021,287:-. |
| APA | Shen, Zelin.,Zhang, Xiaoyan.,Shi, Jianbo.,Lv, Jungang.,Liu, Guangliang.,...&Jiang, Guibin.(2021).Automatic Ethylation-Purge and Trap-GC-ICP-MS for Methylmercury Analysis: Method Validation and Application for Isotope Dilution/Tracing.ATOMIC SPECTROSCOPY,287,-. |
| MLA | Shen, Zelin,et al."Automatic Ethylation-Purge and Trap-GC-ICP-MS for Methylmercury Analysis: Method Validation and Application for Isotope Dilution/Tracing".ATOMIC SPECTROSCOPY 287(2021):-. |
入库方式： OAI收割
来源：生态环境研究中心
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