Assessing the toxicity of bisphenol A and its six alternatives on zebrafish embryo/larvae
文献类型：期刊论文
| 作者 | Gao, Yue ; Li, Aijing; Zhang, Wenjuan; Pang, Shaochen; Liang, Yong; Song, Maoyong
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| 刊名 | AQUATIC TOXICOLOGY
 |
| 出版日期 | 2022-05 |
| 卷号 | 246期号:0页码:106154 |
| 关键词 | DANIO-RERIO OXIDATIVE STRESS HORMONAL BALANCE MESSENGER-RNA UNITED-STATES ANALOGS EXPOSURE EMBRYO MECHANISMS BIODEGRADATION |
| ISSN号 | 0166-445X |
| 英文摘要 | Bisphenol A (BPA) analogues are gradually replacing BPA in the plastics industry. Whether these alternatives are indeed safer than BPA itself, however, remains unclear. Here, we studied the toxicity of BPA and six of its alternatives-BPB, BPC, BPE, BPF, BPAF, and BPAP-using zebrafish embryos/larvae. According to their half lethal concentration (LC50) values, the acute toxicity of BPA and six alternative bisphenols to zebrafish embryos, from highest to lowest, was BPAP approximate to BPAF > BPC > BPB > BPA > BPE > BPF. Under nonlethal concentrations, the tested bisphenols had different toxic effects on development in terms of reducing the hatching rate, frequency of spontaneous movements, and heart rate in the embryo, as well as inducing yolk sac edema, pericardial edema, and spinal deformation in the larvae. The estrogenic activity of BPE, BPF, and BPAF was higher than that of BPA, as shown by vtg1 expression assays. Moreover, BPA and its alternatives increased SOD activity and cell apoptosis in embryos/larvae under nonlethal concentrations. Our findings indicate that BPA alternatives may not be safer than BPA in zebrafish, and that these BPA alternatives should be applied with caution. |
| 源URL | [https://ir.rcees.ac.cn/handle/311016/47646]  |
| 专题 | 生态环境研究中心_环境纳米材料实验室 |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, Key Lab Environm Nanotechnol & Hlth Effects, Beijing 100085, Peoples R China 3.Jianghan Univ, Inst Environm & Hlth, Hubei Key Lab Environm & Hlth Effects Persistent, Wuhan 430056, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gao, Yue,Li, Aijing,Zhang, Wenjuan,et al. Assessing the toxicity of bisphenol A and its six alternatives on zebrafish embryo/larvae[J]. AQUATIC TOXICOLOGY,2022,246(0):106154. |
| APA | Gao, Yue,Li, Aijing,Zhang, Wenjuan,Pang, Shaochen,Liang, Yong,&Song, Maoyong.(2022).Assessing the toxicity of bisphenol A and its six alternatives on zebrafish embryo/larvae.AQUATIC TOXICOLOGY,246(0),106154. |
| MLA | Gao, Yue,et al."Assessing the toxicity of bisphenol A and its six alternatives on zebrafish embryo/larvae".AQUATIC TOXICOLOGY 246.0(2022):106154. |
入库方式： OAI收割
来源：生态环境研究中心
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