A Potent Lead Induces Apoptosis in Pancreatic Cancer Cells
文献类型：期刊论文
| 作者 | Liu ZJ ; Li D ; Zhao WJ ; Zheng XL ; Wang J ; Wang EK |
| 刊名 | plos one
 |
| 出版日期 | 2012 |
| 卷号 | 7期号:6页码:文献号: e37841 |
| 关键词 | CYTOCHROME-C MOLECULAR-MECHANISMS CARCINOMA CELLS INHIBITION RESISTANCE GEMCITABINE STATISTICS PREVENTION CASPASE-3 THERAPY |
| ISSN号 | 1932-6203 |
| 通讯作者 | liu zj |
| 中文摘要 | pancreatic cancer is considered a lethal and treatment-refractory disease. to obtain a potent anticancer drug, the cytotoxic effect of 2-(benzo[d]oxazol-3(2h)-ylmethyl)-5-((cyclohexylamino) methyl)benzene-1,4-diol, dihydrochloride (nsc48693) on human pancreatic cancer cells cfpac-1, miapaca-2, and bxpc-3 was assessed in vitro. the proliferation of cfpac-1, miapaca-2, and bxpc-3 is inhibited with ic50 value of 12.9 +/- 0.2, 20.6 +/- 0.3, and 6.2 +/- 0.6 mu m at 48 h, respectively. this discovery is followed with additional analysis to demonstrate that nsc48693 inhibition is due to induction of apoptosis, including annexin v staining, chromatins staining, and colony forming assays. it is further revealed that nsc48693 induces the release of cytochrome c, reduces mitochondrial membrane potential, generates reactive oxygen species, and activates caspase. these results collectively indicate that nsc48693 mainly induces apoptosis of cfpac-1, miapaca-2, and bxpc-3 cells by the mitochondrial-mediated apoptotic pathway. excitingly, the study highlights an encouraging inhibition effect that human embryonic kidney (hek-293) and liver (hl-7702) cells are more resistant to the antigrowth effect of nsc48693 compared to the three cancer cell lines. from this perspective, nsc48693 should help to open up a new opportunity for the treatment of patients with pancreatic cancer. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000305693200006 |
| 公开日期 | 2013-10-09 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/48823]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Liu ZJ,Li D,Zhao WJ,et al. A Potent Lead Induces Apoptosis in Pancreatic Cancer Cells[J]. plos one,2012,7(6):文献号: e37841. |
| APA | Liu ZJ,Li D,Zhao WJ,Zheng XL,Wang J,&Wang EK.(2012).A Potent Lead Induces Apoptosis in Pancreatic Cancer Cells.plos one,7(6),文献号: e37841. |
| MLA | Liu ZJ,et al."A Potent Lead Induces Apoptosis in Pancreatic Cancer Cells".plos one 7.6(2012):文献号: e37841. |
入库方式： OAI收割
来源：长春应用化学研究所
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