G-Quadruplex as Signal Transducer for Biorecognition Events
文献类型：期刊论文
| 作者 | Lv L ; Guo ZJ ; Wang JH ; Wang EK |
| 刊名 | current pharmaceutical design
 |
| 出版日期 | 2012 |
| 卷号 | 18期号:14页码:2076-2095 |
| 关键词 | WALLED CARBON NANOTUBES GOLD NANOPARTICLES TELOMERASE ACTIVITY FLUORESCENCE DETECTION COLORIMETRIC DETECTION PEROXIDASE-ACTIVITY PROTEIN-DETECTION AQUEOUS-SOLUTION LABEL-FREE IN-VITRO |
| ISSN号 | 1381-6128 |
| 通讯作者 | wang jh |
| 中文摘要 | g-rich nucleic acid oligomers can form g-quadruplexes built by g-tetrads stacked upon each other. the basic building block of the g-quadruplexes is similar, but the formation of different quadruplex structures is highly responsive to the strand stoichiometry, strand orientation, guanine glycosidic torsion angle, connecting loops, and the metal coordination. because of its structural variations and different functions, g-quadruplex applied in biorecognition events can function as a versatile signaling component. a variety of strategies that incorporate g-quadruplex have also been reported. in this review, we mainly discuss g-quadruplex as signal transducer from the following aspects for biorecognition events: analyte-induced g-quadruplex reconfiguration and fluorescence enhancement of small ligand; analyte-induced g-quadruplex reconstruction and formation of dnazyme; stimulus-responsive g-quadruplex refolding and manipulation of electron transfer; stimulus-responsive g-quadruplex and its combination with nanopore systems; small ligand-responsive g-quadruplex stabilization for drug screening; nanomaterial-reponsive g-quadruplex reformation; target-triggered continuous formation of g-quadruplex by dna nanomachine. we have comprehensively described the recent progress in our labs and others. undoubtedly, bioanalytical technology and nanotechnology based on g-quadruplex will continue to grow, leading to develop new diagnostics, therapeutics and drug development. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000304823300018 |
| 公开日期 | 2013-10-09 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/48830]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Lv L,Guo ZJ,Wang JH,et al. G-Quadruplex as Signal Transducer for Biorecognition Events[J]. current pharmaceutical design,2012,18(14):2076-2095. |
| APA | Lv L,Guo ZJ,Wang JH,&Wang EK.(2012).G-Quadruplex as Signal Transducer for Biorecognition Events.current pharmaceutical design,18(14),2076-2095. |
| MLA | Lv L,et al."G-Quadruplex as Signal Transducer for Biorecognition Events".current pharmaceutical design 18.14(2012):2076-2095. |
入库方式： OAI收割
来源：长春应用化学研究所
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