Intestinal Transport of Pure Diester-type Alkaloids from an Aconite Extract across the Caco-2 Cell Monolayer Model
文献类型：期刊论文
| 作者 | Li N ; Tsao R ; Sui ZG ; Ma JW ; Liu ZQ ; Liu ZY |
| 刊名 | planta medica
 |
| 出版日期 | 2012 |
| 卷号 | 78期号:7页码:692-697 |
| 关键词 | PERFORMANCE LIQUID-CHROMATOGRAPHY P-GLYCOPROTEIN QUANTITATIVE-DETERMINATION DRUG INTERACTIONS IN-VITRO DITERPENOID ALKALOIDS MEDIATED TRANSPORT HYPACONITINE PERMEABILITY MESACONITINE |
| ISSN号 | 0032-0943 |
| 通讯作者 | liu zy |
| 中文摘要 | aconitine (ac), mesaconitine (ma), and hypaconitine (ha) are the active alkaloids identified in aconite tuber, an important traditional chinese medicine. the study is aimed to investigate their intestinal transport profiles and potential interaction during the intestinal absorption using the caco-2 cell monolayer model. all three alkaloids had good permeability with p-app values greater than 1 x 10(-6) cm.s(-1). however, ac, ma, and ha in a mixture and as an extract, in both cases with the same content of alkaloids, showed higher transport efficiency in the apical to basolateral, and lower transport efficiency in the basolateral to apical directions. digoxin, as a p-glycoprotein (p-gp) substrate, was substantially effluxed in the basolateral to apical direction but inhibited by the three alkaloids. furthermore, the backwards transport of ma and ha was inhibited by the p-gp inhibitor verapamil. these observations indicated that the three alkaloids may not only be p-gp inhibitors but also its substrates; they interact with each other and can potentially enhance their own bioavailability when taken concomitantly. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000303838000008 |
| 公开日期 | 2013-10-09 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/48832]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Li N,Tsao R,Sui ZG,et al. Intestinal Transport of Pure Diester-type Alkaloids from an Aconite Extract across the Caco-2 Cell Monolayer Model[J]. planta medica,2012,78(7):692-697. |
| APA | Li N,Tsao R,Sui ZG,Ma JW,Liu ZQ,&Liu ZY.(2012).Intestinal Transport of Pure Diester-type Alkaloids from an Aconite Extract across the Caco-2 Cell Monolayer Model.planta medica,78(7),692-697. |
| MLA | Li N,et al."Intestinal Transport of Pure Diester-type Alkaloids from an Aconite Extract across the Caco-2 Cell Monolayer Model".planta medica 78.7(2012):692-697. |
入库方式： OAI收割
来源：长春应用化学研究所
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