Caveolae-mediated endocytosis of biocompatible gold nanoparticles in living Hela cells
文献类型：期刊论文
| 作者 | Hao X ; Wu JZ ; Shan YP ; Cai MJ ; Shang X ; Jiang JG ; Wang HD |
| 刊名 | journal of physics-condensed matter
 |
| 出版日期 | 2012 |
| 卷号 | 24期号:16页码:文献号: 164207 |
| 关键词 | PLASMA-MEMBRANE CLATHRIN ENTRY DNA PARTICLE REMOVAL DEVICES |
| ISSN号 | 0953-8984 |
| 通讯作者 | hao x |
| 中文摘要 | efficient intracellular delivery of gold nanoparticles (aunps) and unraveling the mechanism underlying the intracellular delivery are essential for advancing the applications of aunps toward in vivo imaging and therapeutic interventions. we employed fluorescence microscopy to investigate the internalization mechanism of small-size aunps by living hela cells. herein, we found that the caveolae-mediated endocytosis was the dominant pathway for the intracellular delivery of small-size aunps. the intracellular delivery was suppressed when we depleted the cholesterol with methyl-beta-cyclodextrin (m beta cd); in contrast, the sucrose that disrupts the formation of clathrin-mediated endocytosis did not block the endocytosis of aunps. meanwhile, we examined the intracellular localization of aunps in endocytic vesicles by fluorescent colocalization. this work would provide a potential technique to study the intracellular delivery of small-size nanoparticles for biomedical applications. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000302559200013 |
| 公开日期 | 2013-10-09 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/48836]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Hao X,Wu JZ,Shan YP,et al. Caveolae-mediated endocytosis of biocompatible gold nanoparticles in living Hela cells[J]. journal of physics-condensed matter,2012,24(16):文献号: 164207. |
| APA | Hao X.,Wu JZ.,Shan YP.,Cai MJ.,Shang X.,...&Wang HD.(2012).Caveolae-mediated endocytosis of biocompatible gold nanoparticles in living Hela cells.journal of physics-condensed matter,24(16),文献号: 164207. |
| MLA | Hao X,et al."Caveolae-mediated endocytosis of biocompatible gold nanoparticles in living Hela cells".journal of physics-condensed matter 24.16(2012):文献号: 164207. |
入库方式： OAI收割
来源：长春应用化学研究所
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