Assessing the bioavailability and biotoxicity of spiromesifen and its main metabolite spiromesifen-enol (M01) reveals the defense mechanisms of earthworms (Eisenia fetida)
文献类型：期刊论文
| 作者 | Fang, Jianwei; Wang, Binning; Fang, Kuan; Liu, Tong; Yan, Saihong ; Wang, Xiuguo
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| 刊名 | SCIENCE OF THE TOTAL ENVIRONMENT
 |
| 出版日期 | 2022-03-20 |
| 卷号 | 813期号:0页码:151910 |
| 关键词 | SILVER NANOPARTICLE EXPOSURE OXIDATIVE STRESS RESPONSES CELL-DEATH V-ATPASE TOXICITY SOIL BIOACCUMULATION DINOTEFURAN AUTOPHAGY LYSOSOME |
| ISSN号 | 0048-9697 |
| 英文摘要 | As a promising acaricide and potentially hazardous material, the defense mechanisms of non-target organisms to its exposure are unknown. This study investigates the bioavailability and biotoxicity of spiromesifen and spiromesifen-enol (M01), its main metabolite, in Eisenia fetida. The results showed that MO) was more persistent in the soil environment and E. fetida than spiromesifen. Transcriptome analysis indicated that the spiromesifen- and M01-induced differentially expressed genes (DF.Gs) were mainly enriched in lysasomal and phagosomal pathways. Analysis of the key common DEGs showed that both spiromesifen and M01 significantly influenced the lysosomes, phagosomes, antioxidant systems, and detoxification systems. Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) showed that spiromesifen and M01 damaged E. fetida epidermis and enhanced lysosomal and phagosomal activities. Significant oxidative stress effects were observed at the end of exposure. The hydroxyl free radical (center dot OH-) content and neutral red retention time (NRRT) could serve as sensitive early biomarkers to predict their pollution. These results revealed the synergistic effects of the epidermis, lysosomes, phagosomes, antioxidant systems, and detoxification system in resisting spiromesifen- and M01-induced damage, which could contribute to the defense mechanisms of non-target organisms against these pollutants. |
| 源URL | [https://ir.rcees.ac.cn/handle/311016/47829]  |
| 专题 | 生态环境研究中心_中国科学院饮用水科学与技术重点实验室 |
| 作者单位 | 1.Chinese Acad Agr Sci CAAS, Tobacco Res Inst, Qingdao 266101, Peoples R China 2.China Agr Univ CAU, Coll Land Sci & Technol, Beijing 100083, Peoples R China 3.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, Beijing 100085, Peoples R China |
| 推荐引用方式 GB/T 7714 | Fang, Jianwei,Wang, Binning,Fang, Kuan,et al. Assessing the bioavailability and biotoxicity of spiromesifen and its main metabolite spiromesifen-enol (M01) reveals the defense mechanisms of earthworms (Eisenia fetida)[J]. SCIENCE OF THE TOTAL ENVIRONMENT,2022,813(0):151910. |
| APA | Fang, Jianwei,Wang, Binning,Fang, Kuan,Liu, Tong,Yan, Saihong,&Wang, Xiuguo.(2022).Assessing the bioavailability and biotoxicity of spiromesifen and its main metabolite spiromesifen-enol (M01) reveals the defense mechanisms of earthworms (Eisenia fetida).SCIENCE OF THE TOTAL ENVIRONMENT,813(0),151910. |
| MLA | Fang, Jianwei,et al."Assessing the bioavailability and biotoxicity of spiromesifen and its main metabolite spiromesifen-enol (M01) reveals the defense mechanisms of earthworms (Eisenia fetida)".SCIENCE OF THE TOTAL ENVIRONMENT 813.0(2022):151910. |
入库方式： OAI收割
来源：生态环境研究中心
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