Environmentally relevant concentrations of benzophenones triggered DNA damage and apoptosis in male Chinese rare minnows (Gobiocypris rarus)
文献类型：期刊论文
| 作者 | Yan, Saihong ; Wang, Jun; Zheng, Ziting; Ji, Fenfen; Yan, Liang; Yang, Lihua; Zha, Jinmiao
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| 刊名 | ENVIRONMENT INTERNATIONAL
 |
| 出版日期 | 2022-06 |
| 卷号 | 164期号:0页码:107260 |
| 关键词 | ORGANIC UV-FILTERS WASTE-WATER TREATMENT POLYCYCLIC AROMATIC-HYDROCARBONS CELL-DEATH PRODUCTS TOXICITY EXPOSURE PHOTOGENOTOXICITY GENOTOXICITY BIOMARKERS |
| ISSN号 | 0160-4120 |
| 英文摘要 | Benzophenone-type ultraviolet (UV) filters (BPs) are commonly used as sunscreen agents, fragrance enhancers and plastic additives, and are great threats to aquatic organisms due to their high detected concentrations in the aquatic environment. However, few studies on their toxicity and mechanism in fish have been clearly reported. In this study, Chinese rare minnows (Gobiocypris rarus) were exposed to benzophenone (BP), 2,4-dihydroxybenzophenone (BP-1), and 5-benzoyl-4-hydroxy-2-methoxybenzenesulfonic acid (BP-4) at 5, 50, 500 mu g/L for 28 d to assess their toxicity. Transcriptomics screening showed that cell cycle, DNA replication and repair were significantly altered pathways (p < 0.05). The altered transcripts were similar to those identified by RNA-seq. DNA damage and 8-OHdG levels were significantly increased at 50 and 500 mu g/L groups (p < 0.05). The DNA methylcytosine level was not significantly changed exposure to BP, BP-1 and BP-4. TUNEL assays indicated that hepatic apoptosis was significantly improved at 500 mu g/L BP and BP-4 and 50 and 500 mu g/L BP-1 (p < 0.05), with the significantly increasing the activity of caspase-3, -8 and -9 (p < 0.05). Molecular docking analysis revealed that BP, BP-1 and BP-4 could bind differently to caspase-3 through different binding interactions. Therefore, BP-1 induced more serious oxidative DNA damage and apoptosis by activating caspase-3 than BP and BP-4, which will provide theoretical basis and data support for ecological evaluation of aquatic organisms induced by BPs. |
| 源URL | [https://ir.rcees.ac.cn/handle/311016/47846]  |
| 专题 | 生态环境研究中心_中国科学院饮用水科学与技术重点实验室 |
| 通讯作者 | Zha, Jinmiao |
| 作者单位 | 1.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, Key Lab Drinking Water Sci & Technol, Beijing 100085, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100085, Peoples R China 3.Shandong Agr Univ, Coll Resources & Environm, Key Lab Agr Environm, Tai An 271018, Peoples R China 4.Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China 5.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, Key Lab Drinking Water Sci & Technol, 18 Shuangqing |
| 推荐引用方式 GB/T 7714 | Yan, Saihong,Wang, Jun,Zheng, Ziting,et al. Environmentally relevant concentrations of benzophenones triggered DNA damage and apoptosis in male Chinese rare minnows (Gobiocypris rarus)[J]. ENVIRONMENT INTERNATIONAL,2022,164(0):107260. |
| APA | Yan, Saihong.,Wang, Jun.,Zheng, Ziting.,Ji, Fenfen.,Yan, Liang.,...&Zha, Jinmiao.(2022).Environmentally relevant concentrations of benzophenones triggered DNA damage and apoptosis in male Chinese rare minnows (Gobiocypris rarus).ENVIRONMENT INTERNATIONAL,164(0),107260. |
| MLA | Yan, Saihong,et al."Environmentally relevant concentrations of benzophenones triggered DNA damage and apoptosis in male Chinese rare minnows (Gobiocypris rarus)".ENVIRONMENT INTERNATIONAL 164.0(2022):107260. |
入库方式： OAI收割
来源：生态环境研究中心
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