Low doses and lifecycle exposure of waterborne antidepressants in zebrafish model: A survey on sperm traits, reproductive behaviours, and
文献类型：期刊论文
| 作者 | Hong, Xiangsheng ; Chen, Rui; Zhang, Le; Yan, Liang; Li, Jiasu; Zha, Jinmiao
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| 刊名 | SCIENCE OF THE TOTAL ENVIRONMENT
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| 出版日期 | 2022-08-01 |
| 卷号 | 832期号:0页码:155017 |
| ISSN号 | 0048-9697 |
| 关键词 | ENVIRONMENTALLY RELEVANT CONCENTRATIONS PHARMACEUTICAL POLLUTANT FLUOXETINE MEDAKA ORYZIAS-LATIPES TESTICULAR DEVELOPMENT SELECTIVE UPTAKE FATHEAD MINNOWS FISH BIOACCUMULATION VENLAFAXINE IMPACTS |
| 英文摘要 | Venlafaxine and citalopram have been commonly found in surface water and may disrupt fish reproduction, yet the long-term impact and the underlying mechanism are largely unknown. Here, zebrafish were exposed to 0.1-100 mu g/L venlafaxine and citalopram for their entire life cycle from embryo to adult, respectively. After exposure for 180 days, the lowest observable effective concentration (LOEC) of venlafaxine and citalopram to significantly reduce the mean number of egg production in adults were 10 and 1 mu g/L, respectively, whereas the fertilization rate displayed no significant changes. Further, we investigated the impacts of venlafaxine and citalopram in a reproductive context, including sperm quality and reproductive behaviour. In contrast, venlafaxine and citalopram exposure did not affect sperm quality but caused a reduction of reproductive behaviour (e.g., mating duration and mating interval) of adults exposed to 1-10 mu g/L of the antidepressant. Transcriptomic profiling of the whole ovary revealed that lifecycle venlafaxine and citalopram exposure significantly affected the Na+/Cl- dependent neurotransmitter transporters signaling. Moreover, immune system-mediated ovarian regeneration and creatine metabolism regulated energy metabolism were proposed as the novel mechanism in the observed effects. Taken together, our results highlight the risk of lifecycle venlafaxine and citalopram exposure to fish reproduction and provide novel perspectives for unveiling the mechanism of female reproductive dysfunction. |
| 源URL | [https://ir.rcees.ac.cn/handle/311016/47872]  |
| 专题 | 生态环境研究中心_中国科学院饮用水科学与技术重点实验室 |
| 通讯作者 | Zha, Jinmiao |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Beijing Key Lab Ind Wastewater Treatment & Reuse, Res Ctr Ecoenvironm Sci, Beijing, Peoples R China 3.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, Key Lab Drinking Water Sci & Technol, 18 Shuangqing Rd, Beijing 100085, Peoples R China 4.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Aquat Chem, Beijing 100085, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hong, Xiangsheng,Chen, Rui,Zhang, Le,et al. Low doses and lifecycle exposure of waterborne antidepressants in zebrafish model: A survey on sperm traits, reproductive behaviours, and[J]. SCIENCE OF THE TOTAL ENVIRONMENT,2022,832(0):155017. |
| APA | Hong, Xiangsheng,Chen, Rui,Zhang, Le,Yan, Liang,Li, Jiasu,&Zha, Jinmiao.(2022).Low doses and lifecycle exposure of waterborne antidepressants in zebrafish model: A survey on sperm traits, reproductive behaviours, and.SCIENCE OF THE TOTAL ENVIRONMENT,832(0),155017. |
| MLA | Hong, Xiangsheng,et al."Low doses and lifecycle exposure of waterborne antidepressants in zebrafish model: A survey on sperm traits, reproductive behaviours, and".SCIENCE OF THE TOTAL ENVIRONMENT 832.0(2022):155017. |
入库方式： OAI收割
来源：生态环境研究中心
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