Metabonomic and transcriptomic modulations of HepG2 cells induced by the CuO-catalyzed formation of disinfection byproducts from biofilm extracellular polymeric substances in copper pipes
文献类型：期刊论文
| 作者 | Hu, Jun; Qu, Jiajia; Deng, Lin; Dong, Huiyu ; Jiang, Liying; Yu, Jianming; Yue, Siqing; Qian, Haifeng; Dai, Qizhou; Qiang, Zhimin
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| 刊名 | WATER RESEARCH
 |
| 出版日期 | 2022-06-01 |
| 卷号 | 216期号:0页码:118318 |
| ISSN号 | 0043-1354 |
| 关键词 | BROMIDE-CONTAINING WATERS CORROSION PRODUCTS CHLORINATION TOXICITY BROMATE HALOACETONITRILES SPECIATION BEHAVIOR PACKAGE |
| 英文摘要 | Cupric oxide (CuO) is able to catalyze the reactions among disinfectant, extracellular polymeric substances (EPS) and bromide (Br- ) in copper pipes, which may deteriorate the water quality. This study aimed to investigate the metabonomic and transcriptomic modulations of HepG2 cells caused by the CuO-catalyzed formation of disinfection byproducts (DBPs) from EPS. The presence of CuO favored the substitution reactions of chlorine and bromine with EPS, inducing a higher content of total organic halogen (TOX). In addition, DBPs were shifted from chlorinated species to brominated species. A total of 182 differential metabolites (DMs) and 437 differentially expressed genes (DEGs) were identified, which were jointly involved in 38 KEGG pathways. Topology analysis indicates that glycerophospholipid and purine metabolism were disturbed most obviously. During glycerophospholipid metabolism, the differential expression of genes GPATs, AGPATs, LPINs and DGKs impacted the conversion of glycerol-3-phosphate to 2-diacyl-sn-glycerol, which further affected the conversion among phosphatidylcholine, phosphatidylserine and phosphocholines. During purine metabolism, it was mainly the differential expression of genes POLRs, RPAs, RPBs, RPCs, ENTPDs and CDs that impacted the transformation of RNA into guanine-, xanthosine-, inosine-and adenosine monophosphate, which were further successively transformed into their corresponding nucleosides and purines. The study provides an omics perspective to assess the potential adverse effects of overall DBPs formed in copper pipes on human. |
| 源URL | [https://ir.rcees.ac.cn/handle/311016/47874]  |
| 专题 | 生态环境研究中心_中国科学院饮用水科学与技术重点实验室 |
| 作者单位 | 1.Zhejiang Univ Technol, Coll Environm, 18 Chao Wang Rd, Hangzhou 310014, Peoples R China 2.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, Key Lab Drinking Water Sci & Technol, 18 Shuang-qing Rd, Beijing 100085, Peoples R China 3.Univ Chinese Acad Sci, 19 Yu Quan Rd, Beijing 100049, Peoples R China 4.Southeast Univ, Dept Municipal Engn, 2 Southeast Univ Rd, Nanjing 211189, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hu, Jun,Qu, Jiajia,Deng, Lin,et al. Metabonomic and transcriptomic modulations of HepG2 cells induced by the CuO-catalyzed formation of disinfection byproducts from biofilm extracellular polymeric substances in copper pipes[J]. WATER RESEARCH,2022,216(0):118318. |
| APA | Hu, Jun.,Qu, Jiajia.,Deng, Lin.,Dong, Huiyu.,Jiang, Liying.,...&Qiang, Zhimin.(2022).Metabonomic and transcriptomic modulations of HepG2 cells induced by the CuO-catalyzed formation of disinfection byproducts from biofilm extracellular polymeric substances in copper pipes.WATER RESEARCH,216(0),118318. |
| MLA | Hu, Jun,et al."Metabonomic and transcriptomic modulations of HepG2 cells induced by the CuO-catalyzed formation of disinfection byproducts from biofilm extracellular polymeric substances in copper pipes".WATER RESEARCH 216.0(2022):118318. |
入库方式： OAI收割
来源：生态环境研究中心
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