Environmental concentrations of 2, 4-DTBP cause immunotoxicity in zebrafish (Danio rerio) and may elicit ecological risk to wildlife
文献类型：期刊论文
| 作者 | Liu, Wang ; Zhang, Jiye; Liang, Xuefang; Wang, Yuchen; Liu, Ruimin; Zhang, Ruiqing; Zha, Jinmiao; Martyniuk, Christopher J.
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| 刊名 | CHEMOSPHERE
 |
| 出版日期 | 2022 |
| 卷号 | 308页码:136465-1-10 |
| 关键词 | 2 4-DTBP Immunotoxicity Anti-Inflammation Intestinal barrier NF-?B pathway |
| ISSN号 | 0045-6535 |
| 英文摘要 | Synthetic phenolic antioxidant 2,4-di-tert-butylphenol (2,4-DTBP) has gained growing concerns due to relatively high concentrations in aquatic ecosystems. There are, however, significant knowledge gaps regarding its po-tential toxicity to aquatic organisms. In this study, zebrafish (Danio rerio) larvae were exposed to 0.01, 0.1, or 1 mu M 2,4-DTBP for 6 d. Transcriptomic analysis of larvae revealed that biological processes related to anti-inflammatory function of macrophage M2 lineage were inhibited by 0.01 mu M 2,4-DTBP. Decreases of tran-scripts related to the IL1B-MYD88-NF-Kappa B pathway (i.e., il1b, il1rl1, myd88, irak4, irak1, traf6, ikbkg, nfkbia, nfkb) and protein levels of NF-Kappa B in larvae intestine confirmed anti-inflammatory effects of 2,4-DTBP. Subsequently, larvae exposed to 2,4-DTBP were challenged with E. coli and showed higher survival rate, suggesting sustained activation of inflammation via LPS can be attenuated by 2,4-DTBP. Moreover, histological examination revealed that intestine barrier was compromised and there was an imbalance of intestine macrophage homeostasis. Food intake was also reduced following exposure to 0.1 and 1 mu M 2,4-DTBP. In addition, a risk assessment revealed that 2,4-DTBP in surface water pose low to high ecological risks to aquatic organisms. Taken together, exposure to environmentally relevant concentrations of 2,4-DTBP could negatively affect immune response in zebrafish and may elicit ecological risk in fish population. |
| 源URL | [https://ir.rcees.ac.cn/handle/311016/48565]  |
| 专题 | 生态环境研究中心_中国科学院饮用水科学与技术重点实验室 |
| 作者单位 | 1.University of Florida 2.State University System of Florida 3.Research Center for Eco-Environmental Sciences (RCEES) 4.Chinese Academy of Sciences 5.Inner Mongolia University |
| 推荐引用方式 GB/T 7714 | Liu, Wang,Zhang, Jiye,Liang, Xuefang,et al. Environmental concentrations of 2, 4-DTBP cause immunotoxicity in zebrafish (Danio rerio) and may elicit ecological risk to wildlife[J]. CHEMOSPHERE,2022,308:136465-1-10. |
| APA | Liu, Wang.,Zhang, Jiye.,Liang, Xuefang.,Wang, Yuchen.,Liu, Ruimin.,...&Martyniuk, Christopher J..(2022).Environmental concentrations of 2, 4-DTBP cause immunotoxicity in zebrafish (Danio rerio) and may elicit ecological risk to wildlife.CHEMOSPHERE,308,136465-1-10. |
| MLA | Liu, Wang,et al."Environmental concentrations of 2, 4-DTBP cause immunotoxicity in zebrafish (Danio rerio) and may elicit ecological risk to wildlife".CHEMOSPHERE 308(2022):136465-1-10. |
入库方式： OAI收割
来源：生态环境研究中心
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