Human coding RNA editing is generally nonadaptive
文献类型：期刊论文
| 作者 | Xu, Guixia1 ; Zhang, Jianzhi1
|
| 刊名 | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
 |
| 出版日期 | 2014 |
| 卷号 | 111期号:10页码:3769-3774 |
| 关键词 | deleterious neutral synonymous |
| ISSN号 | 0027-8424 |
| DOI | 10.1073/pnas.1321745111 |
| 文献子类 | Article |
| 英文摘要 | Impairment of RNA editing at a handful of coding sites causes severe disorders, prompting the view that coding RNA editing is highly advantageous. Recent genomic studies have expanded the list of human coding RNA editing sites by more than 100 times, raising the question of how common advantageous RNA editing is. Analyzing 1,783 human coding A-to-G editing sites, we show that both the frequency and level of RNA editing decrease as the importance of a site or gene increases; that during evolution, edited As are more likely than unedited As to be replaced with Gs but not with Ts or Cs; and that among nonsynonymously edited As, those that are evolutionarily least conserved exhibit the highest editing levels. These and other observations reveal the overall nonadaptive nature of coding RNA editing, despite the presence of a few sites in which editing is clearly beneficial. We propose that most observed coding RNA editing results from tolerable promiscuous targeting by RNA editing enzymes, the original physiological functions of which remain elusive. |
| 学科主题 | Multidisciplinary Sciences |
| 出版地 | WASHINGTON |
| WOS关键词 | DNA-SEQUENCE DIFFERENCES ; HIGHLY EXPRESSED PROTEINS ; HUMAN TRANSCRIPTOME ; WIDESPREAD RNA ; SEQ DATA ; GLUR-B ; GENES ; EVOLUTION ; SITES ; IDENTIFICATION |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000332564800038 |
| 出版者 | NATL ACAD SCIENCES |
| 资助机构 | National Institutes of Health [R01GM103232] ; National Natural Science Foundation of China [31100170] ; NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM103232] Funding Source: NIH RePORTER |
| 源URL | [http://ir.ibcas.ac.cn/handle/2S10CLM1/27192]  |
| 专题 | 植物研究所_系统与进化植物学研究中心_系统与进化植物学研究中心_学位论文 |
| 作者单位 | 1.Chinese Acad Sci, Inst Bot, State Key Lab Systemat & Evolutionary Bot, Beijing 100093, Peoples R China 2.Univ Michigan, Dept Ecol & Evolutionary Biol, Ann Arbor, MI 48109 USA |
| 推荐引用方式 GB/T 7714 | Xu, Guixia,Zhang, Jianzhi. Human coding RNA editing is generally nonadaptive[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2014,111(10):3769-3774. |
| APA | Xu, Guixia,&Zhang, Jianzhi.(2014).Human coding RNA editing is generally nonadaptive.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,111(10),3769-3774. |
| MLA | Xu, Guixia,et al."Human coding RNA editing is generally nonadaptive".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 111.10(2014):3769-3774. |
入库方式： OAI收割
来源：植物研究所
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