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Biosynthesis, regulation, and domestication of bitterness in cucumber

文献类型：期刊论文

作者Shang, Yi2; Ma, Yongshuo3; Zhou, Yuan4; Zhang, Huimin3; Duan, Lixin5; Chen, Huiming6; Zeng, Jianguo4; Zhou, Qian; Wang, Shenhao; Gu, Wenjia7
刊名SCIENCE
出版日期2014
卷号346期号:6213页码:1084-1088
ISSN号0036-8075
DOI10.1126/science.1259215
文献子类Article
英文摘要Cucurbitacins are triterpenoids that confer a bitter taste in cucurbits such as cucumber, melon, watermelon, squash, and pumpkin. These compounds discourage most pests on the plant and have also been shown to have antitumor properties. With genomics and biochemistry, we identified nine cucumber genes in the pathway for biosynthesis of cucurbitacin C and elucidated four catalytic steps. We discovered transcription factors Bl (Bitter leaf) and Bt (Bitter fruit) that regulate this pathway in leaves and fruits, respectively. Traces in genomic signatures indicated that selection imposed on Bt during domestication led to derivation of nonbitter cucurbits from their bitter ancestors.
学科主题Multidisciplinary Sciences
出版地WASHINGTON
电子版国际标准刊号1095-9203
WOS关键词SPECIALIZED METABOLISM ; BIOLOGICAL-ACTIVITIES ; CUCURBITACIN-C ; CANCER-CELLS ; SATIVUS L ; PLANTS ; GENE ; RESISTANCE ; PATHWAY
WOS研究方向Science & Technology - Other Topics
语种英语
WOS记录号WOS:000345763400035
出版者AMER ASSOC ADVANCEMENT SCIENCE
资助机构Spanish Consolider-Ingenio program [CPAN CSD2007-00042, MultiDark CSD2009-00064] ; Academy of Finland [127740] ; DFG Cluster of Excellence ; Croatian Science Foundation (HrZZ) [09/176] ; University of Rijeka [13.12.1.3.02] ; DFG Collaborative Research Centers [SFB823/C4, SFB876/C3] ; Polish MNiSzW grant [745/N-HESS-MAGIC/2010/0] ; DFG [WI 1860/10-1] ; ERDF ; Spanish MINECO [FPA2012-39502, JCI-2011-10019, AYA2009-13036-C02-02, AYA2012-38491-C02-01] ; Generalitat Valenciana [PROMETEO/2009/104] ; COST [MP0905] ; national research councils ; European Commission [283393]
源URL[http://ir.ibcas.ac.cn/handle/2S10CLM1/27044]  
专题中科院植物分子生理学重点实验室
作者单位1.Nihon Univ, Sch Pharm, Tokyo 1018308, Japan
2.Chinese Acad Agr Sci, Key Lab Biol & Genet Improvement Hort Crops, Sinodutch Joint Lab Hort Genom, Inst Vegetables & Flowers,Minist Agr, Beijing 100081, Peoples R China
3.Chinese Acad Agr Sci, Agr Genom Inst Shenzhen, Shenzhen 518124, Peoples R China
4.Nanjing Agr Univ, Coll Life Sci, Nanjing 210095, Jiangsu, Peoples R China
5.Hunan Agr Univ, Hort & Landscape Coll, Natl Chinese Med Herbs Technol Ctr, Changsha 410128, Hunan, Peoples R China
6.Chinese Acad Sci, Inst Bot, Beijing 100093, Peoples R China
7.Hunan Acad Agr Sci, Hunan Vegetable Res Inst, Changsha 410125, Hunan, Peoples R China
8.Wuhan Univ, Coll Life Sci, Wuhan 430072, Peoples R China
9.Chinese Acad Sci, Inst Microbiol, Beijing 100190, Peoples R China
10.Bouwmeester, Harro J.] Wageningen Univ, Lab Plant Physiol, NL-6700 Wageningen, Netherlands
推荐引用方式
GB/T 7714		 Shang, Yi,Ma, Yongshuo,Zhou, Yuan,et al. Biosynthesis, regulation, and domestication of bitterness in cucumber[J]. SCIENCE,2014,346(6213):1084-1088.
APA Shang, Yi.,Ma, Yongshuo.,Zhou, Yuan.,Zhang, Huimin.,Duan, Lixin.,...&Huang, Sanwen.(2014).Biosynthesis, regulation, and domestication of bitterness in cucumber.SCIENCE,346(6213),1084-1088.
MLA Shang, Yi,et al."Biosynthesis, regulation, and domestication of bitterness in cucumber".SCIENCE 346.6213(2014):1084-1088.

入库方式： OAI收割

来源：植物研究所

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