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The non-metabolizable glucose analog D-glucal inhibits aflatoxin biosynthesis and promotes kojic acid production in Aspergillus flavus

文献类型：期刊论文

作者Zhang, Jin-Dan; Han, Lida; Yan, Shijuan; Liu, Chun-Ming
刊名BMC MICROBIOLOGY
出版日期2014
卷号14
关键词D-glucal D-galactal Aflatoxin biosynthesis Aspergillus flavus Metabolomics
ISSN号1471-2180
DOI10.1186/1471-2180-14-95
文献子类Article
英文摘要Background: Aflatoxins (AFs) are potent carcinogenic compounds produced by several Aspergillus species, which pose serious threats to human health. As sugar is a preferred carbohydrate source for AF production, we examined the possibility of using sugar analogs to inhibit AF biosynthesis. Results: We showed that although D-glucal cannot be utilized by A. flavus as the sole carbohydrate source, it inhibited AF biosynthesis and promoted kojic acid production without affecting mycelial growth when applied to a glucose-containing medium. The inhibition occurred before the production of the first stable intermediate, norsolorinic acid, suggesting a complete inhibition of the AF biosynthetic pathway. Further studies showed that exogenous D-glucal in culture led to reduced accumulation of tricarboxylic acid (TCA) cycle intermediates and reduced glucose consumption, indicating that glycolysis is inhibited. Expression analyses revealed that D-glucal suppressed the expression of AF biosynthetic genes but promoted the expression of kojic acid biosynthetic genes. Conclusions: D-glucal as a non-metabolizable glucose analog inhibits the AF biosynthesis pathway by suppressing the expression of AF biosynthetic genes. The inhibition may occur either directly through interfering with glycolysis, or indirectly through reduced oxidative stresses from kojic acid biosynthesis.
学科主题Microbiology
出版地LONDON
WOS关键词CARBON-SOURCES ; RESTING CELLS ; PARASITICUS ; GENE ; SPORULATION ; METABOLISM ; GENOMICS ; PEPTONE ; PATHWAY ; OXIDASE
WOS研究方向Microbiology
语种英语
WOS记录号WOS:000335416300002
出版者BIOMED CENTRAL LTD
资助机构Key Innovation Project [KSCX2-YW-N-033] ; Chinese Academy of Sciences
源URL[http://ir.ibcas.ac.cn/handle/2S10CLM1/27378]  
专题中科院植物分子生理学重点实验室
作者单位1.[Zhang, Jin-Dan
2.Han, Lida
3.Yan, Shijuan
4.Chinese Acad Sci, Inst Bot, Key Lab Plant Mol Physiol, Beijing 100093, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Jin-Dan,Han, Lida,Yan, Shijuan,et al. The non-metabolizable glucose analog D-glucal inhibits aflatoxin biosynthesis and promotes kojic acid production in Aspergillus flavus[J]. BMC MICROBIOLOGY,2014,14.
APA Zhang, Jin-Dan,Han, Lida,Yan, Shijuan,&Liu, Chun-Ming.(2014).The non-metabolizable glucose analog D-glucal inhibits aflatoxin biosynthesis and promotes kojic acid production in Aspergillus flavus.BMC MICROBIOLOGY,14.
MLA Zhang, Jin-Dan,et al."The non-metabolizable glucose analog D-glucal inhibits aflatoxin biosynthesis and promotes kojic acid production in Aspergillus flavus".BMC MICROBIOLOGY 14(2014).

入库方式： OAI收割

来源：植物研究所

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