中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 地质与地球物理研究所
  3. 中国科学院地质与地球物理研究所
  4. 中国科学院地球与行星物理重点实验室
Hypomagnetic Field Exposure Affecting Gut Microbiota, Reactive Oxygen Species Levels, and Colonic Cell Proliferation in Mice

文献类型：期刊论文

作者Zhan, Aisheng2,3,4; Luo, Yukai2,3,4; Qin, Huafeng2,5; Lin, Wei3,4; Tian, Lanxiang1,3,4
刊名BIOELECTROMAGNETICS
出版日期2022-11-26
页码14
关键词hypomagnetic field gut microbiota diversity reactive oxygen species colonic cell proliferation
ISSN号0197-8462
DOI10.1002/bem.22427
英文摘要The gut microbiota has been considered one of the key factors in host health, which is influenced by many environmental factors. The geomagnetic field (GMF) represents one of the important environmental conditions for living organisms. Previous studies have shown that the elimination of GMF, the so-called hypomagnetic field (HMF), could affect the physiological functions and resistance to antibiotics of some microorganisms. However, whether long-term HMF exposure could alter the gut microbiota to some extent in mammals remains unclear. Here, we investigated the effects of long-term (8- and 12-week) HMF exposure on the gut microbiota in C57BL/6J mice. Our results clearly showed that 8-week HMF significantly affected the diversity and function of the mouse gut microbiota. Compared with the GMF group, the concentrations of short-chain fatty acids tended to decrease in the HMF group. Immunofluorescence analysis showed that HMF promoted colonic cell proliferation, concomitant with an increased level of reactive oxygen species (ROS). To our knowledge, this is the first in vivo finding that long-term HMF exposure could affect the mouse gut microbiota, ROS levels, and colonic cell proliferation in the colon. Moreover, the changes in gut microbiota can be restored by returning mice to the GMF environment, thus the possible harm to the microbiota caused by HMF exposure can be alleviated. (c) 2022 Bioelectromagnetics Society.
WOS关键词ZERO-MAGNETIC-FIELD ; BUTYRATE ; BACTERIA ; COLITIS ; MUCOSA
WOS研究方向Life Sciences & Biomedicine - Other Topics ; Biophysics
语种英语
WOS记录号WOS:000891052800001
出版者WILEY
源URL[http://ir.iggcas.ac.cn/handle/132A11/107645]  
专题地质与地球物理研究所_中国科学院地球与行星物理重点实验室
地质与地球物理研究所_岩石圈演化国家重点实验室
通讯作者Tian, Lanxiang
作者单位1.Chinese Acad Sci, Inst Geol & Geophys, Beijing 100029, Peoples R China
2.Univ Chinese Acad Sci, Coll Earth & Planetary Sci, Beijing, Peoples R China
3.Chinese Acad Sci, France China Joint Lab Evolut & Dev Magnetotact Mu, Beijing, Peoples R China
4.Chinese Acad Sci, Inst Geol & Geophys, Key Lab Earth & Planetary Phys, Beijing, Peoples R China
5.Chinese Acad Sci, Inst Geol & Geophys, State Key Lab Lithospher Evolut, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Zhan, Aisheng,Luo, Yukai,Qin, Huafeng,et al. Hypomagnetic Field Exposure Affecting Gut Microbiota, Reactive Oxygen Species Levels, and Colonic Cell Proliferation in Mice[J]. BIOELECTROMAGNETICS,2022:14.
APA Zhan, Aisheng,Luo, Yukai,Qin, Huafeng,Lin, Wei,&Tian, Lanxiang.(2022).Hypomagnetic Field Exposure Affecting Gut Microbiota, Reactive Oxygen Species Levels, and Colonic Cell Proliferation in Mice.BIOELECTROMAGNETICS,14.
MLA Zhan, Aisheng,et al."Hypomagnetic Field Exposure Affecting Gut Microbiota, Reactive Oxygen Species Levels, and Colonic Cell Proliferation in Mice".BIOELECTROMAGNETICS (2022):14.

入库方式： OAI收割

来源：地质与地球物理研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。