Effects of hypomagnetic field on adult hippocampal neurogenic niche and neurogenesis in mice
文献类型：期刊论文
| 作者 | Luo, Yukai1,2,3; Zhan, Aisheng1,2,3; Fan, Yunchang1,2,3; Tian, Lanxiang1,2,4 |
| 刊名 | FRONTIERS IN PHYSICS
 |
| 出版日期 | 2022-11-25 |
| 卷号 | 10页码:12 |
| ISSN号 | 2296-424X |
| 关键词 | hypomagnetic field double-wrapped coils neurogenic niche adult hippocampal neurogenesis cognitive function |
| DOI | 10.3389/fphy.2022.1075198 |
| 英文摘要 | The elimination of geomagnetic field (GMF), also called hypomagnetic field (HMF), is one of the major environmental hazards faced by deep-space astronauts and the workers in magnetically shielded rooms on Earth. We previously reported that long-term HMF exposure impaired adult hippocampal neurogenesis (AHN) and cognition by reducing endogenous reactive oxygen species (ROS) levels in adult neural stem cells (aNSCs). In addition to the aNSCs themselves, adult neurogenesis is also regulated by the local environment, i.e., the neurogenic niche. Neurogenic niche is mainly composed of astrocyte, microglia, and vascular system. However, whether the HMF exposure affects the neurogenic niche in hippocampus remains unknown. In this study, we investigated the effects of the HMF exposure on the neurogenic niche and adult neurogenesis in hippocampus, as well as the cognitive function in mice. The HMF is simulated by using the newly upgraded double-wrapped coils, different with our previous coils, which are capable of providing a very low-strength static magnetic field and identical electromagnetic field background between the HMF group and the GMF group. Here, we for the first time clearly revealed that 8-week HMF exposure significantly induced microglia activation and increased the number of astrocytes in hippocampal dentate gyrus (DG), suggesting the abnormalities in the neurogenic niche. Meanwhile, 8-week HMF exposure also markedly reduced proliferation and differentiation of aNSCs in the DG, and impaired the cognitive behavior of mice, consistent with our previous findings. In addition, we also found that 8-week HMF exposure significantly induced anxiety-like behaviors of mice. In summary, this study indicates that 8-week HMF exposure induces the neurogenic niche abnormalities, contributing to the AHN impairments, thus leads to the cognitive dysfunction and anxiety-like behaviors in mice. |
| WOS关键词 | AMYGDALA ; ANXIETY ; MICROGLIA ; MEMORY ; FEAR ; ASTROCYTES ; MODULATION ; EXPOSURE ; STRESS ; CNS |
| 资助项目 | National Natural Science Foundation of China ; Strategic Priority Research Program of the Chinese Academy of Sciences[42074073] ; Strategic Priority Research Program of the Chinese Academy of Sciences[41621004] ; [XDA17010501] |
| WOS研究方向 | Physics |
| 语种 | 英语 |
| 出版者 | FRONTIERS MEDIA SA |
| WOS记录号 | WOS:000895558200001 |
| 资助机构 | National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences |
| 源URL | [http://ir.iggcas.ac.cn/handle/132A11/106998]  |
| 专题 | 地质与地球物理研究所_中国科学院地球与行星物理重点实验室 |
| 通讯作者 | Tian, Lanxiang |
| 作者单位 | 1.Chinese Acad Sci, Inst Geol & Geophys, Key Lab Earth & Planetary Phys, Beijing, Peoples R China 2.Chinese Acad Sci, France China Joint Lab Evolut & Dev Magnetotact Mu, Beijing, Peoples R China 3.Univ Chinese Acad Sci, Coll Earth & Planetary Sci, Beijing, Peoples R China 4.Chinese Acad Sci, Inst Geol & Geophys, Beijing Natl Observ Space Environm, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Luo, Yukai,Zhan, Aisheng,Fan, Yunchang,et al. Effects of hypomagnetic field on adult hippocampal neurogenic niche and neurogenesis in mice[J]. FRONTIERS IN PHYSICS,2022,10:12. |
| APA | Luo, Yukai,Zhan, Aisheng,Fan, Yunchang,&Tian, Lanxiang.(2022).Effects of hypomagnetic field on adult hippocampal neurogenic niche and neurogenesis in mice.FRONTIERS IN PHYSICS,10,12. |
| MLA | Luo, Yukai,et al."Effects of hypomagnetic field on adult hippocampal neurogenic niche and neurogenesis in mice".FRONTIERS IN PHYSICS 10(2022):12. |
入库方式： OAI收割
来源：地质与地球物理研究所
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