Abstract

The research on clinical high-risk for psychosis is a hotspot in recent years, which is helpful to the early identification and early intervention of psychosis. White matter fibers are the important structural basis of complex information transmission function among brain regions. The existing literatures show that there are abnormal white matter microstructures in individuals at clinical high-risk for psychosis, which is related to their clinical symptoms and social function. Diffusion tensor imaging is the only non-invasive technique to study the microstructure of brain white matter. This paper reviews the existing evidences of microstructural abnormalities of white matter at clinical high-risk for psychosis by diffusion tensor imaging, in order to comprehensively analyze the potential neurobiomarkers in the early stage of the disease and the pathological evolution characteristics in the development of the disease.

摘要

目的

对精神病临床高危人群的研究是近年来的研究热点，有助于疾病的早期识别及早期干预。脑白质纤维束是脑区间复杂信息传递功能的重要结构基础，既有文献表明，精神病临床高危个体存在白质微结构异常，且与其临床症状及功能相关。弥散张量磁共振成像是当前唯一非侵入性地研究脑白质微结构的技术。本文对利用弥散张量成像对精神病临床高危白质微结构异常的现有证据进行综述，旨在综合分析疾病早期潜在的神经生物标志及疾病发展中的病理演变特征。

国家自然科学基金 （81901355） 

北京市自然科学基金 （7192081）