Iron homeostasis in the heart: Molecular mechanisms and pharmacological implications
文献类型：期刊论文
| 作者 | Zhang, Jiawei3; Song, Yijing3; Li, You3; Lin, Han-Bin1,4; Fang, Xuexian2,3 |
| 刊名 | JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
 |
| 出版日期 | 2023 |
| 卷号 | 174页码:15-24 |
| 关键词 | Iron metabolism Heart Cardiovascular diseases Mitochondrion Oxidative stress |
| ISSN号 | 0022-2828 |
| DOI | 10.1016/j.yjmcc.2022.11.001 |
| 通讯作者 | Fang, Xuexian(xfang@hznu.edu.cn) |
| 英文摘要 | Iron is necessary for the life of practically all living things, yet it may also harm people toxically. Accordingly, humans and other mammals have evolved an effective and tightly regulatory system to maintain iron homeostasis in healthy tissues, including the heart. Iron deficiency is common in patients with heart failure, and is associated with worse prognosis in this population; while the prevalence of iron overload-related cardiovascular disorders is also increasing. Therefore, enhancing the therapy of patients with cardiovascular disorders requires a thorough understanding of iron homeostasis. Here, we give readers an overview of the fundamental mechanisms governing systemic iron homeostasis as well as the most recent knowledge about the intake, storage, use, and export of iron from the heart. Genetic mouse models used for investigation of iron metabolism in various in vivo scenarios are summarized and highlighted. We also go through different clinical conditions and therapeutic approaches that target cardiac iron dyshomeostasis. Finally, we conclude the review by outlining the present knowledge gaps and important open questions in this field in order to guide future research on cardiac iron metabolism. |
| WOS关键词 | REDUCED EJECTION FRACTION ; FERRIC CARBOXYMALTOSE ; MITOCHONDRIAL FERRITIN ; BETA-THALASSEMIA ; MICROCYTIC ANEMIA ; 5-AMINOLEVULINATE SYNTHASE ; TRANSFERRIN RECEPTOR ; HEMOCHROMATOSIS GENE ; EXERCISE CAPACITY ; CALCIUM-CHANNEL |
| 资助项目 | National Natural Science Foundation of China[82170644] ; National Natural Science Foundation of China[31900835] ; National Natural Science Foundation of China[82100391] ; Natural Science Foundation of Zhejiang Province[LY22C110002] ; High-level New R&D Institute of Department of Science and Technology of Guangdong Province[2019B090904008] ; High-level Innovative Research Institute of Department of Science and Technology of Guangdong Province[2021B0909050003] |
| WOS研究方向 | Cardiovascular System & Cardiology ; Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000922001500002 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/303291]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Fang, Xuexian |
| 作者单位 | 1.Chinese Acad Sci, Zhongshan Inst Drug Discovery, SIMM, Zhongshan, Peoples R China 2.Hangzhou Normal Univ, Key Lab Elemene Class Anticanc Chinese Med, Hangzhou, Peoples R China 3.Hangzhou Normal Univ, Sch Publ Hlth, Dept Nutr & Toxicol, Bldg 7 Shenyuan,2318 Yuhangtang Rd, Hangzhou 311121, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Jiawei,Song, Yijing,Li, You,et al. Iron homeostasis in the heart: Molecular mechanisms and pharmacological implications[J]. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY,2023,174:15-24. |
| APA | Zhang, Jiawei,Song, Yijing,Li, You,Lin, Han-Bin,&Fang, Xuexian.(2023).Iron homeostasis in the heart: Molecular mechanisms and pharmacological implications.JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY,174,15-24. |
| MLA | Zhang, Jiawei,et al."Iron homeostasis in the heart: Molecular mechanisms and pharmacological implications".JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 174(2023):15-24. |
入库方式： OAI收割
来源：上海药物研究所
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