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Enantiomeric pairs of macrocyclic acylphloroglucinols from Syzygium szemaoense

文献类型：期刊论文

作者Huang, Jin-Chang2,3; Hong Xu, Hong-1; Shi, Qing2,3; Lei, Chun3; Li, Jing-Ya1; Hou, Ai-Jun2,3
刊名BIOORGANIC CHEMISTRY
出版日期2023-03-01
卷号132页码:6
关键词Syzygium szemaoense Acylphloroglucinol enantiomers Death -associated protein kinase-related apoptosis inducing protein kinase 2 ATP citrate lyase
ISSN号0045-2068
DOI10.1016/j.bioorg.2023.106381
通讯作者Li, Jing-Ya(jyli@simm.ac.cn) ; Hou, Ai-Jun(ajhou@sjtu.edu.cn)
英文摘要Two enantiomeric pairs of macrocyclic acylphloroglucinols (1a/1b and 2a/2b) with an unprecedented carbon skeleton featuring a bicyclo[12.3.1]octadecane core, together with an undescribed biogenetically related longchain acylphloroglucinol (3), were isolated from Syzygium szemaoense. Their structures were fully established by spectroscopic method, X-ray crystallographic analysis, and ECD calculation. Compounds 1b and 2a/2b exhibited inhibition against death-associated protein kinase-related apoptosis inducing protein kinase 2 (DRAK2) and ATP citrate lyase (ACLY), respectively.
WOS关键词DERIVATIVES ; INHIBITORS ; DRAK2 ; ANTIOXIDANT ; DISCOVERY ; APOPTOSIS ; JAMBOS ; KINASE
资助项目National Natural Science Foundation of China[22277074] ; National Natural Science Foundation of China[82170872]
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
语种英语
WOS记录号WOS:000925022100001
出版者ACADEMIC PRESS INC ELSEVIER SCIENCE
源URL[http://119.78.100.183/handle/2S10ELR8/303294]  
专题中国科学院上海药物研究所
通讯作者Li, Jing-Ya; Hou, Ai-Jun
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
2.Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 200240, Peoples R China
3.Fudan Univ, Sch Pharm, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Huang, Jin-Chang,Hong Xu, Hong-,Shi, Qing,et al. Enantiomeric pairs of macrocyclic acylphloroglucinols from Syzygium szemaoense[J]. BIOORGANIC CHEMISTRY,2023,132:6.
APA Huang, Jin-Chang,Hong Xu, Hong-,Shi, Qing,Lei, Chun,Li, Jing-Ya,&Hou, Ai-Jun.(2023).Enantiomeric pairs of macrocyclic acylphloroglucinols from Syzygium szemaoense.BIOORGANIC CHEMISTRY,132,6.
MLA Huang, Jin-Chang,et al."Enantiomeric pairs of macrocyclic acylphloroglucinols from Syzygium szemaoense".BIOORGANIC CHEMISTRY 132(2023):6.

入库方式： OAI收割

来源：上海药物研究所

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