Full title: Rational Design of Organelle-targeted Fluorescent Probes: Insights from Artificial Intelligence
文献类型：期刊论文
| 作者 | Dong, Jie1; Qian, Jie2; Yu, Kunqian3 ; Huang, Shuai1; Cheng, Xiang1; Chen, Fei1; Jiang, Hualiang3; Zeng, Wenbin1
|
| 刊名 | RESEARCH
 |
| 出版日期 | 2023-01-25 |
| 卷号 | 2023页码:33 |
| ISSN号 | 2096-5168 |
| 通讯作者 | Zeng, Wenbin(wbzeng@hotmail.com) |
| 英文摘要 | Monitoring the physiological changes of organelles is essential for understanding the local biological information of cells, and for improving the diagnosis and therapy of diseases. Currently, fluorescent probes are considered as the most powerful tools for imaging and have been widely applied in biomedical fields. However, the expected targeting effects of these probes are often inconsistent with the real experiments. The design of fluorescent probes mainly depends on the empirical knowledge of researchers, which was inhibited by limited chemical space and low efficiency. Herein, we proposed a novel multi-level framework for the prediction of organelle-targeted fluorescent probes by employing advanced artificial intelligence algorithms. In this way, not only the targeting mechanism could be interpreted beyond intuitions but also a quick evaluation method could be established for the rational design. Furthermore, the targeting and imaging powers of the optimized and synthesized probes based on this methodology were verified by quantitative calculation and experiments. |
| 资助项目 | National Natural Science Foundation of China[22003078] ; National Natural Science Foundation of China[82272067] ; National Natural Science Foundation of China[M-0696] ; Central South University Innovation -Driven Research Program[2023CXQD004] ; Central South University Innovation -Driven Research Program[2023QYJC021] |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| 出版者 | AMER ASSOC ADVANCEMENT SCIENCE |
| WOS记录号 | WOS:000924836200001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/303300]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Zeng, Wenbin |
| 作者单位 | 1.Cent South Univ, Xiangya Sch Pharmaceut Sci, Changsha, Peoples R China 2.Cent South Univ Forestry & Technol, Natl Engn Res Ctr Rice & Byproduct Deep Proc, Sch Food Sci & Engn, Changsha 410004, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Drug Discovery & Design Ctr, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Dong, Jie,Qian, Jie,Yu, Kunqian,et al. Full title: Rational Design of Organelle-targeted Fluorescent Probes: Insights from Artificial Intelligence[J]. RESEARCH,2023,2023:33. |
| APA | Dong, Jie.,Qian, Jie.,Yu, Kunqian.,Huang, Shuai.,Cheng, Xiang.,...&Zeng, Wenbin.(2023).Full title: Rational Design of Organelle-targeted Fluorescent Probes: Insights from Artificial Intelligence.RESEARCH,2023,33. |
| MLA | Dong, Jie,et al."Full title: Rational Design of Organelle-targeted Fluorescent Probes: Insights from Artificial Intelligence".RESEARCH 2023(2023):33. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。