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Guided Isolation of An Uncommon Cembranoid Orthoester, Sarcotortin A, and Three Skeletal Diverse Terpenoids from the Hainan Soft Coral Sarcophyton tortuosum Based on Molecular Networking Strategy

文献类型：期刊论文

作者Chen, Zi-Hui1,2; Yu, Dan-Dan3; Li, Cong1; Su, Ming-Zhi3; Wu, Qihao1; Zhang, Zai-Yong1; Wang, Jian-Rong1; Li, Jia1; Guo, Yue-Wei1,2,3
刊名CHEMISTRY-A EUROPEAN JOURNAL
出版日期2023-02-13
页码12
ISSN号0947-6539
关键词GNPS Sarcophyton tuotorsum soft corals stereochemistry terpenoids
DOI10.1002/chem.202203487
通讯作者Li, Jia(jli@simm.ac.cn) ; Guo, Yue-Wei(ywguo@simm.ac.cn)
英文摘要Applying the emerging molecular networking strategy, an uncommon cembranoid orthoester, sarcotortin A (1), featuring a 3/14/8/5-fused scaffold, an unusual eunicellane-type diterpenoid, sarcotorolide A (2), and two new biscembranoids, ximaolides M and N (7 and 8), along with nine known terpenoids 3-6 and 9-13 were isolated from the Hainan soft coral Sarcophyton tortuosum. The structure and absolute configuration of all new compounds were established by a combination of spectroscopic data, X-ray diffraction analysis, and/or quantum chemical computational approaches. The plausible biogenetic relationship among these skeletally different terpenoids was proposed and discussed. In in vitro bioassay, new compound 7 exhibited a remarkable inhibitory activity against protein tyrosine phosphatases 1B (PTP1B) with the IC50 value of 8.06 mu M. In addition, compounds 4 and 10 displayed significant inhibitory effects on lipopolysaccharide (LPS)-induced inflammatory responses in RAW264.7 macrophages cells with the IC50 values of 19.13 and 16.45 mu M, respectively. Compound 9 showed interesting cytotoxicity against H1975, MDA-MB231, A549, and H1299 cancer cell lines with IC50 values of 31.59, 34.96, 43.87, and 27.93 mu M, respectively.
WOS关键词PROBABLE BIOGENETIC PRECURSOR ; BISCEMBRANOIDS ; LOBOPHYTUM
资助项目National Natural Science Foundation of China[81991521] ; SKLDR/SIMM Project[SIMM2103ZZ-06]
WOS研究方向Chemistry
语种英语
出版者WILEY-V C H VERLAG GMBH
WOS记录号WOS:000931166700001
源URL[http://119.78.100.183/handle/2S10ELR8/303312]  
专题新药研究国家重点实验室
通讯作者Li, Jia; Guo, Yue-Wei
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China
2.Univ Chinese Acad Sci, 19 A Yuquan Rd, Beijing 100049, Peoples R China
3.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Shandong, Peoples R China
推荐引用方式
GB/T 7714		 Chen, Zi-Hui,Yu, Dan-Dan,Li, Cong,et al. Guided Isolation of An Uncommon Cembranoid Orthoester, Sarcotortin A, and Three Skeletal Diverse Terpenoids from the Hainan Soft Coral Sarcophyton tortuosum Based on Molecular Networking Strategy[J]. CHEMISTRY-A EUROPEAN JOURNAL,2023:12.
APA Chen, Zi-Hui.,Yu, Dan-Dan.,Li, Cong.,Su, Ming-Zhi.,Wu, Qihao.,...&Guo, Yue-Wei.(2023).Guided Isolation of An Uncommon Cembranoid Orthoester, Sarcotortin A, and Three Skeletal Diverse Terpenoids from the Hainan Soft Coral Sarcophyton tortuosum Based on Molecular Networking Strategy.CHEMISTRY-A EUROPEAN JOURNAL,12.
MLA Chen, Zi-Hui,et al."Guided Isolation of An Uncommon Cembranoid Orthoester, Sarcotortin A, and Three Skeletal Diverse Terpenoids from the Hainan Soft Coral Sarcophyton tortuosum Based on Molecular Networking Strategy".CHEMISTRY-A EUROPEAN JOURNAL (2023):12.

入库方式： OAI收割

来源：上海药物研究所

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