Could IL-25 be a potential therapeutic target for intestinal inflammatory diseases?
文献类型：期刊论文
| 作者 | Chen, Jie1,4; Wang, Yingshu4; Shen, Lan4; Xiu, Yanfeng3,4; Wang, Bing1,2 |
| 刊名 | CYTOKINE & GROWTH FACTOR REVIEWS
 |
| 出版日期 | 2023-02-01 |
| 卷号 | 69页码:43-50 |
| ISSN号 | 1359-6101 |
| 关键词 | IL-25 Type-2 immunity Inflammatory bowel disease |
| DOI | 10.1016/j.cytogfr.2022.07.001 |
| 通讯作者 | Xiu, Yanfeng(xiuyanfeng@shutcm.edu.cn) ; Wang, Bing(bwang@simm.ac.cn) |
| 英文摘要 | As a member of the IL-17 cytokine family, IL-25 (also called IL-17E) induces and sustains type 2 immunity. IL-25, which is mainly produced by intestinal epithelial cells, has been gradually investigated in recent years for its function in intestinal inflammation but is not yet fully understood. This review summarizes the expression and function of IL-25 in the intestine, especially the progression of its regulatory role on type 2 immunity-related cells. Finally, we discuss the dual role of IL-25 based on inflammatory bowel disease to inform research on targeting IL-25 for the treatment of intestinal inflammatory diseases. |
| WOS关键词 | INNATE LYMPHOID-CELLS ; EPITHELIAL-CELLS ; TYPE-2 IMMUNITY ; TUFT CELLS ; ULCERATIVE-COLITIS ; RECOMBINANT IL-25 ; MUCOSAL IMMUNITY ; BARRIER FUNCTION ; BOWEL-DISEASE ; T-CELLS |
| 资助项目 | Program of Shanghai Committee of Science and Technology, China[21ZR1475200] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Cell Biology |
| 语种 | 英语 |
| 出版者 | ELSEVIER SCI LTD |
| WOS记录号 | WOS:000931787200001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/303318]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Xiu, Yanfeng; Wang, Bing |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut Res, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut Res, 501 Hai ke Rd, Shanghai 201203, Peoples R China 3.Shanghai Univ Tradit Chinese Med, Sch Pharm, 1200 Cai Lun Rd, Shanghai 201203, Peoples R China 4.Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Jie,Wang, Yingshu,Shen, Lan,et al. Could IL-25 be a potential therapeutic target for intestinal inflammatory diseases?[J]. CYTOKINE & GROWTH FACTOR REVIEWS,2023,69:43-50. |
| APA | Chen, Jie,Wang, Yingshu,Shen, Lan,Xiu, Yanfeng,&Wang, Bing.(2023).Could IL-25 be a potential therapeutic target for intestinal inflammatory diseases?.CYTOKINE & GROWTH FACTOR REVIEWS,69,43-50. |
| MLA | Chen, Jie,et al."Could IL-25 be a potential therapeutic target for intestinal inflammatory diseases?".CYTOKINE & GROWTH FACTOR REVIEWS 69(2023):43-50. |
入库方式： OAI收割
来源：上海药物研究所
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