Oral delivery of nucleic acid therapeutics: Challenges, strategies, and opportunities
文献类型：期刊论文
| 作者 | Jiang, Xiaohe3,4; Wang, Ning3,4; Liu, Chang3,4; Zhuo, Yan3,5; Liang, Li2,3; Gan, Yong1,3,4 ; Yu, Miaorong3,4
|
| 刊名 | DRUG DISCOVERY TODAY
 |
| 出版日期 | 2023-04-01 |
| 卷号 | 28期号:4页码:7 |
| 关键词 | nucleic acid oral delivery gastrointestinal barriers nanoparticles gastrointestinal diseases |
| ISSN号 | 1359-6446 |
| DOI | 10.1016/j.drudis.2023.103507 |
| 通讯作者 | Yu, Miaorong(mryu@simm.ac.cn) |
| 英文摘要 | In recent decades, advances in chemical synthesis and delivery systems have accelerated the development of therapeutic nucleic acids, several of which have been approved by the Us Food and Drug Administration (FDA). Oral nucleic acid delivery is preferred because of its simplicity and patient compliance, but it still presents distinct challenges. The negative charge, hydrophilicity, and large molecular weight of nucleic acids combined with in vivo gastrointestinal (GI) barriers (e.g., acidic pH, enzymes, mucus, and intestinal epithelial cells) severely hinder their delivery efficacy. Recently, various nanoparticles (NPs), ranging from polymeric to lipid-based (L)NPs and extracellular vesicles (EVs), have been extensively explored to address these obstacles. In this review, we describe the physiological barriers in the GI tract and summarize recent advances in NP-based oral nucleic acid therapeutics. |
| WOS关键词 | MESSENGER-RNA DELIVERY ; EXTRACELLULAR VESICLES ; DRUG-DELIVERY ; LIPID NANOPARTICLES ; SIRNA ; OLIGONUCLEOTIDES ; FORMULATIONS ; STABILITY ; COMPLEXES ; EXOSOMES |
| 资助项目 | National Natural Science Foundation of China[82073773] ; National Natural Science Foundation of China[82025032] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000926950600001 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/303321]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Yu, Miaorong |
| 作者单位 | 1.Natl Inst Food & Drug Control, NMPA Key Lab Qual Res & Evaluat Pharmaceut Excipie, Beijing 100050, Peoples R China 2.Nanjing Univ Chinese Med, Sch Pharm, Nanjing 210023, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, State Key Lab Drug Res, Shanghai 201203, Peoples R China 4.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 5.Nanchang Univ, Sch Pharmaceut Sci, Dept Pharmacol, Nanchang 330000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jiang, Xiaohe,Wang, Ning,Liu, Chang,et al. Oral delivery of nucleic acid therapeutics: Challenges, strategies, and opportunities[J]. DRUG DISCOVERY TODAY,2023,28(4):7. |
| APA | Jiang, Xiaohe.,Wang, Ning.,Liu, Chang.,Zhuo, Yan.,Liang, Li.,...&Yu, Miaorong.(2023).Oral delivery of nucleic acid therapeutics: Challenges, strategies, and opportunities.DRUG DISCOVERY TODAY,28(4),7. |
| MLA | Jiang, Xiaohe,et al."Oral delivery of nucleic acid therapeutics: Challenges, strategies, and opportunities".DRUG DISCOVERY TODAY 28.4(2023):7. |
入库方式： OAI收割
来源：上海药物研究所
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