中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 上海药物研究所
  3. 中国科学院上海药物研究所
  4. 新药研究国家重点实验室
Nitric Oxide-Loaded Bioinspired Lipoprotein Normalizes Tumor Vessels To Improve Intratumor Delivery and Chemotherapy of Albumin-Bound Paclitaxel Nanoparticles

文献类型：期刊论文

作者Wu, Yao3,4; Xie, Honglei2; Li, Yongping5; Bao, Xinyue3; Lu, Guo-Liang1; Wen, Jingyuan1; Gao, Yuan3; Li, Yaping4; Zhang, Zhiwen2,3
刊名NANO LETTERS
出版日期2023-01-26
页码9
关键词Nitric oxide (NO) bioinspired lipoprotein albumin-bound paclitaxel nanoparticles tumor penetration vascular normalization
ISSN号1530-6984
DOI10.1021/acs.nanolett.2c04312
通讯作者Gao, Yuan(yuan_gao@fudan.edu.cn) ; Li, Yaping(ypli@simm.ac.cn) ; Zhang, Zhiwen(zhangzhiwen@fudan.edu.cn)
英文摘要The disorganized vasculatures in tumors represent a substantial challenge of intratumor nanomedicine delivery to exert the anticancer effects. Herein, we rationally designed a glutathione (GSH)-activated nitric oxide (NO) donor loaded bioinspired lipoprotein system (NO-BLP) to normalize tumor vessels and then promote the delivery efficiency of sequential albumin-bound paclitaxel nanoparticles (PAN) in tumors. NO-BLP exhibited higher tumor accumulation and deeper penetration versus the counterpart liposomal formulation (NO-Lipo) in 4T1 breast cancer tumors, thus producing notable vascular normalization efficacy and causing a 2.33-fold increase of PAN accumulation. The sequential strategy of NO-BLP plus PAN resulted in an 81.03% inhibition of tumor growth in 4T1 tumors, which was better than the NO-BLP monotherapy, PAN monotherapy, and the counterpart NO-Lipo plus PAN treatment. Therefore, the bioinspired lipoprotein of NO-BLP provides an encouraging platform to normalize tumor vessels and promote intratumor delivery of nanomedicines for effective cancer treatment.
WOS关键词VASCULAR NORMALIZATION ; DRUG-DELIVERY ; BLOOD-VESSELS ; CANCER ; NANOMEDICINES ; PROGRESS
资助项目National Key R&D Program of China[2022YFC2304303] ; National Natural Science Foundation of China[32271461] ; National Natural Science Foundation of China[32130058] ; National Natural Science Foundation of China[81972392] ; Key Specialty Construction Project of Pudong Health and Family Planning Commission of Shanghai[PWZzk2017-32]
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种英语
WOS记录号WOS:000924025700001
出版者AMER CHEMICAL SOC
源URL[http://119.78.100.183/handle/2S10ELR8/303358]  
专题新药研究国家重点实验室
通讯作者Gao, Yuan; Li, Yaping; Zhang, Zhiwen
作者单位1.Univ Auckland, Auckland 1142, New Zealand
2.Yantai Inst Mat Med, Yantai Key Lab Nanomed & Adv Preparat, Yantai 264000, Shandong, Peoples R China
3.Fudan Univ, Sch Pharm, Shanghai 201203, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
5.Fudan Univ, Shanghai Pudong Hosp, Pudong Med Ctr, Dept Breast Surg, Shanghai 201399, Peoples R China
推荐引用方式
GB/T 7714		 Wu, Yao,Xie, Honglei,Li, Yongping,et al. Nitric Oxide-Loaded Bioinspired Lipoprotein Normalizes Tumor Vessels To Improve Intratumor Delivery and Chemotherapy of Albumin-Bound Paclitaxel Nanoparticles[J]. NANO LETTERS,2023:9.
APA Wu, Yao.,Xie, Honglei.,Li, Yongping.,Bao, Xinyue.,Lu, Guo-Liang.,...&Zhang, Zhiwen.(2023).Nitric Oxide-Loaded Bioinspired Lipoprotein Normalizes Tumor Vessels To Improve Intratumor Delivery and Chemotherapy of Albumin-Bound Paclitaxel Nanoparticles.NANO LETTERS,9.
MLA Wu, Yao,et al."Nitric Oxide-Loaded Bioinspired Lipoprotein Normalizes Tumor Vessels To Improve Intratumor Delivery and Chemotherapy of Albumin-Bound Paclitaxel Nanoparticles".NANO LETTERS (2023):9.

入库方式： OAI收割

来源：上海药物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。