Smart Nanosensitizers for Activatable Sono-Photodynamic Immunotherapy of Tumors by Redox-Controlled Disassembly
文献类型：期刊论文
| 作者 | Liu, Lingjun1; Zhang, Junya2; An, Ruibing2; Xue, Qi3; Cheng, Xi1; Hu, Yuxuan2; Huang, Zheng2; Wu, Luyan2; Zeng, Wenhui2; Miao, Yinxing2 |
| 刊名 | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
 |
| 出版日期 | 2023-01-31 |
| 页码 | 13 |
| ISSN号 | 1433-7851 |
| 关键词 | Bimodal Imaging Disassembly Immunotherapy Photodynamic Therapy Sonodynamic Therapy |
| DOI | 10.1002/anie.202217055 |
| 通讯作者 | Liu, Hong(hliu@simm.ac.cn) ; Ye, Deju(dejuye@nju.edu.cn) |
| 英文摘要 | Tumor-targeted and stimuli-activatable nanosensitizers are highly desirable for cancer theranostics. However, designing smart nanosensitizers with multiple imaging signals and synergistic therapeutic activities switched on is challenging. Herein, we report tumor-targeted and redox-activatable nanosensitizers (1-NPs) for sono-photodynamic immunotherapy of tumors by molecular co-assembly and redox-controlled disassembly. 1-NPs show a high longitudinal relaxivity (r(1)=18.7 +/- 0.3 mM(-1) s(-1)), but "off" dual fluorescence (FL) emission (at 547 and 672 nm), "off" sono-photodynamic therapy and indoleamine 2,3-dioxygenase 1 (IDO1) inhibition activities. Upon reduction by glutathione (GSH), 1-NPs rapidly disassemble and remotely release small molecules 2-Gd, Zn-PPA-SH and NLG919, concurrently switching on (1) dual FL emission, (2) sono-photodynamic therapy and (3) IDO1 inhibition activities. After systemic injection, 1-NPs are effective for bimodal FL and magnetic resonance (MR) imaging-guided sono-photodynamic immunotherapy of orthotropic breast and brain tumors in mice under combined ultrasound (US) and 671-nm laser irradiation. |
| WOS关键词 | THERAPY ; NANOTECHNOLOGY ; NANOPARTICLES ; STRATEGIES |
| 资助项目 | National Key R&D Program of China[2021YFA0910003] ; National Key R&D Program of China[2020YFA0713801] ; National Natural Science Foundation of China[82130105] ; National Natural Science Foundation of China[82121005] ; National Natural Science Foundation of China[22274074] ; National Natural Science Foundation of China[22137003] ; Fundamental Research Funds for the Central Universities[020514380251] ; Natural Science Foundation of Jiangsu Province[BK20202004] ; State Key Laboratory of Analytical Chemistry for Life Science[543ZZXM2201] ; Excellent Research Program of Nanjing University[ZYJH004] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| WOS记录号 | WOS:000922309000001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/303361]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Liu, Hong; Ye, Deju |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Key Lab Receptor Res, Shanghai 201203, Peoples R China 2.Nanjing Univ, Chem & Biomed Innovat Ctr Chem, Sch Chem & Chem Engn, State Key Lab Analyt Chem Life Sci, Nanjing 210023, Peoples R China 3.Nanjing Univ, Sch Chem & Chem Engn, State Key Lab Coordinat Chem, Nanjing 210023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Lingjun,Zhang, Junya,An, Ruibing,et al. Smart Nanosensitizers for Activatable Sono-Photodynamic Immunotherapy of Tumors by Redox-Controlled Disassembly[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2023:13. |
| APA | Liu, Lingjun.,Zhang, Junya.,An, Ruibing.,Xue, Qi.,Cheng, Xi.,...&Ye, Deju.(2023).Smart Nanosensitizers for Activatable Sono-Photodynamic Immunotherapy of Tumors by Redox-Controlled Disassembly.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,13. |
| MLA | Liu, Lingjun,et al."Smart Nanosensitizers for Activatable Sono-Photodynamic Immunotherapy of Tumors by Redox-Controlled Disassembly".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2023):13. |
入库方式： OAI收割
来源：上海药物研究所
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