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Megastigmane sesquiterpenoids from Saussurea medusa and their anti-inflammatory activities

文献类型：期刊论文

作者Cao, Jing-Ya1,4,5; Dong, Qi4,5; Wang, Zhi-Yao3; Zhao, Ye2; Ren, Yu2; Mei, Li-Juan4,5; Tao, Yan-Duo4,5; Yu, Rui-Tao4,5
刊名NATURAL PRODUCT RESEARCH
出版日期2022-11-09
页码9
关键词Saussurea medusa megastigmane sesquiterpenoid anti-inflammatory activity iNOS enzyme
ISSN号1478-6419
DOI10.1080/14786419.2022.2146689
通讯作者Tao, Yan-Duo(tyd@nwipb.cas.cn) ; Yu, Rui-Tao(yuruitao@nwipb.cas.cn)
英文摘要Objectives: An ethanol extract of the whole plants of Saussurea medusa had been investigated to find novel anti-inflammatory sesquiterpenoids. Methods: Extensive spectroscopic data and chemical methods were applied to elucidate the structures of the compounds. Results: One new megastigmane sesquiterpenoid (1), along with 11 known analogues (2-12), were obtained from S. medusa. All isolates, except compounds 3 and 6, were mentioned from the studied plant for the first time. Compounds 1, 2, 4, 5, 7, 8 and 12 were firstly isolated from the genus Saussurea. Compounds 2, 9 and 10 were found to inhibit the lipopolysaccharide (LPS)-induced release of NO by RAW264.7 cells with IC50 values ranging from 21.1 +/- 1.7 to 46.7 +/- 1.9 mu M. Furthermore, iNOS expression experiment was performed to examine the interactions between the active compounds and the iNOS enzyme.
WOS关键词ABSOLUTE-CONFIGURATION ; CHEMICAL-CONSTITUENTS ; STRUCTURE ELUCIDATION ; LEAVES ; ALPHA
资助项目Natural Science Foundation of Qinghai Province[2022-ZJ-930] ; science and innovation platform for the development and construction of special project of Key Laboratory of Tibetan Medicine Research of Qinghai Province[2022-ZJ-Y03] ; Key R&D and promotion projects in Henan Province of Henan Academy of Sciences[212102310352] ; Key R&D and promotion projects in Henan Province of Henan Academy of Sciences[220613048] ; Key R&D and promotion projects in Henan Province of Henan Academy of Sciences[210913009]
WOS研究方向Chemistry ; Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000883267200001
出版者TAYLOR & FRANCIS LTD
源URL[http://119.78.100.183/handle/2S10ELR8/303506]  
专题新药研究国家重点实验室
通讯作者Tao, Yan-Duo; Yu, Rui-Tao
作者单位1.Univ Chinese Acad Sci, Beijing, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai, Peoples R China
3.Henan Acad Sci, Zhengzhou, Peoples R China
4.Chinese Acad Sci, Northwest Inst Plateau Biol, Qinghai Prov Key Lab Tibetan Med Res, Xining, Peoples R China
5.Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Tibetan Med Res, Xining, Peoples R China
推荐引用方式
GB/T 7714		 Cao, Jing-Ya,Dong, Qi,Wang, Zhi-Yao,et al. Megastigmane sesquiterpenoids from Saussurea medusa and their anti-inflammatory activities[J]. NATURAL PRODUCT RESEARCH,2022:9.
APA Cao, Jing-Ya.,Dong, Qi.,Wang, Zhi-Yao.,Zhao, Ye.,Ren, Yu.,...&Yu, Rui-Tao.(2022).Megastigmane sesquiterpenoids from Saussurea medusa and their anti-inflammatory activities.NATURAL PRODUCT RESEARCH,9.
MLA Cao, Jing-Ya,et al."Megastigmane sesquiterpenoids from Saussurea medusa and their anti-inflammatory activities".NATURAL PRODUCT RESEARCH (2022):9.

入库方式： OAI收割

来源：上海药物研究所

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