Effects of Nemacystus decipiens polysaccharide on mice with antibiotic associated diarrhea and colon inflammation
文献类型：期刊论文
| 作者 | Pan, Haoyu1,3,4; Chen, Xia1,4; Wang, PeiPei1,4 ; Peng, Junfeng1,2,4; Li, Judong1,2,4; Ding, Kan1,3,4
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| 刊名 | FOOD & FUNCTION
 |
| 出版日期 | 2023-02-06 |
| 卷号 | 14期号:3页码:1627-1635 |
| ISSN号 | 2042-6496 |
| DOI | 10.1039/d1fo02813h |
| 通讯作者 | Ding, Kan() |
| 英文摘要 | Antibiotic associated diarrhea (AAD) is a common side effect of antibiotic therapy in which gut microbiota plays an important role in the disease. However, the function of gut microbiota in this disease is still not entirely clear. Polysaccharides have shown strong activity in shaping gut microbiota. Whether the polysaccharide can intervene with the microbiota to improve ADD has not been determined. In this study, we extract crude polysaccharides from Nemacystus decipiens (N. decipiens), a traditional Chinese medicine (TCM), named NDH0. The crude polysaccharide NDH0 might significantly relieve the symptom of mice with AAD, including a reduction in body weight, shortening of cecum index and the infiltration of inflammatory cells into the colon. NDH0-treated mice exhibited more abundant gut microbial diversity; significantly increased the abundance of Muribaculum, Lactobacillus, and Bifidobacterium and decreased the abundance of Enterobacter and Clostridioides at genus level. NDH0 treatment down-regulated the level of pro-inflammatory cytokines, including IL-1 beta and IL-6 in colon tissue. NDH0 protected the integrity of colon tissues and partially inactivated the related inflammation pathway by maintaining occludin and SH2-containing Inositol 5 '-Phosphatase (SHIP). NDH0 could alleviate symptoms of diarrhea by modulating gut microbiota composition, improving intestinal integrity and reducing inflammation. The underlying protective mechanism was to reduce the abundance of opportunistic pathogens and maintain SHIP protein expression. Collectively, our results demonstrated the role of NDH0 as a potential intestinal protective agent in gut dysbiosis. |
| WOS关键词 | CLOSTRIDIUM-DIFFICILE ; MICROBIOME ; MECHANISMS ; PREVENTION ; DIVERSITY ; BIOLOGY |
| 资助项目 | National Natural Science Foundation of China[81903762] ; Ministry of Science and Technology, the People's Republic of China[2019ZX09735001] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Food Science & Technology |
| 语种 | 英语 |
| WOS记录号 | WOS:000919310300001 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/303519]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Ding, Kan |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Key Lab Receptor Res, Glycochemistry & Glycobiol Lab, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China 2.Naval Med Univ, Shanghai Changzheng Hosp, 415 Fengyang Rd, Shanghai 200003, Peoples R China 3.Shanghai Univ Tradit Chinese Med, Inst Interdisciplinary Integrat Med Res, 1200 Cai Lun Rd, Shanghai 201203, Peoples R China 4.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Pan, Haoyu,Chen, Xia,Wang, PeiPei,et al. Effects of Nemacystus decipiens polysaccharide on mice with antibiotic associated diarrhea and colon inflammation[J]. FOOD & FUNCTION,2023,14(3):1627-1635. |
| APA | Pan, Haoyu,Chen, Xia,Wang, PeiPei,Peng, Junfeng,Li, Judong,&Ding, Kan.(2023).Effects of Nemacystus decipiens polysaccharide on mice with antibiotic associated diarrhea and colon inflammation.FOOD & FUNCTION,14(3),1627-1635. |
| MLA | Pan, Haoyu,et al."Effects of Nemacystus decipiens polysaccharide on mice with antibiotic associated diarrhea and colon inflammation".FOOD & FUNCTION 14.3(2023):1627-1635. |
入库方式： OAI收割
来源：上海药物研究所
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