Highly Twisted Conformation Thiopyrylium Photosensitizers for In Vivo Near Infrared-II Imaging and Rapid Inactivation of Coronavirus
文献类型：期刊论文
| 作者 | Liu, Yishen1,2,3,4,8; Gu, Meijia2; Ding, Qihang2,3,4,5; Zhang, Zhiyun2,3,4,5; Gong, Wanxia2,9,10; Yuan, Yuncong2; Miao, Xiaofei6,7; Ma, Huili11,12; Hong, Xuechuan2,9,10; Hu, Wenbo6,7 |
| 刊名 | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
 |
| 出版日期 | 2023-01-18 |
| 页码 | 11 |
| 关键词 | Coronavirus Inactivation Intersystem Crossing NIR-II Imaging Photosensitizer Triplet State |
| ISSN号 | 1433-7851 |
| DOI | 10.1002/anie.202214875 |
| 通讯作者 | Hu, Wenbo(iamwbhu@nwpu.edu.cn) ; Xiao, Yuling(yxiao@bwh.harvard.edu) |
| 英文摘要 | Despite significant effort, a majority of heavy-atom-free photosensitizers have short excitation wavelengths, thereby hampering their biomedical applications. Here, we present a facile approach for developing efficient near-infrared (NIR) heavy-atom-free photosensitizers. Based on a series of thiopyrylium-based NIR-II (1000-1700 nm) dyads, we found that the star dyad HD with a sterically bulky and electron-rich moiety exhibited configuration torsion and significantly enhanced intersystem crossing (ISC) compared to the parent dyad. The electron excitation characteristics of HD changed from local excitation (LE) to charge transfer (CT)-domain, contributing to a approximate to 6-fold reduction in energy gap (Delta E-ST), a approximate to 10-fold accelerated ISC process, and a approximate to 31.49-fold elevated reactive oxygen species (ROS) quantum yield. The optimized SP@HD-PEG(2K) lung-targeting dots enabled real-time NIR-II lung imaging, which precisely guided rapid pulmonary coronavirus inactivation. |
| 资助项目 | National Key R&D Program of China[2020YFA0908800] ; NSFC[82273796] ; NSFC[82111530209] ; NSFC[21763002] ; NSFC[62175201] ; Shenzhen Science and Technology Research Grant[JCY20220530140605012] ; Shenzhen Science and Technology Research Grant[JCYJ20190808152019182] ; Hubei Province Scientific and Technical Innovation Key Project[2020BAB058] ; Double Thousand Plan of Jiangxi Province[jxsq2020102130] ; Translational Medicine and Interdisciplinary Research Joint Fund of Zhongnan Hospital of Wuhan University[ZNJC202209] ; Tibet Autonomous Region 2022 COVID-19 Prevention and Control Programs for Science and Technology Development, Wuhan University Graduate Student Exchange Program Special Scholarship |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000914807900001 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/303522]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Hu, Wenbo; Xiao, Yuling |
| 作者单位 | 1.Harvard Med Sch, Brigham & Womens Hosp, Dept Anesthesiol, Boston, MA USA 2.Wuhan Univ, Zhongnan Hosp, Sch Pharmaceut Sci, State Key Lab Virol,Dept Cardiol, Wuhan 430071, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China 5.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Peoples R China 6.Northwestern Polytech Univ, Frontiers Sci Ctr Flexible Elect, Xian 710072, Peoples R China 7.Northwestern Polytech Univ, Xian Inst Flexible Elect IFE, Xian 710072, Peoples R China 8.Harvard Med Sch, Brigham & Womens Hosp, Ctr Nanomed, Boston, MA USA 9.Gannan Normal Univ, Chem & Chem Engn Coll, Jiangxi Key Lab Organopharmaceut Chem, Ganzhou 341000, Jiangxi, Peoples R China 10.Wuhan Univ, Shenzhen Inst, Shenzhen 518057, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Yishen,Gu, Meijia,Ding, Qihang,et al. Highly Twisted Conformation Thiopyrylium Photosensitizers for In Vivo Near Infrared-II Imaging and Rapid Inactivation of Coronavirus[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2023:11. |
| APA | Liu, Yishen.,Gu, Meijia.,Ding, Qihang.,Zhang, Zhiyun.,Gong, Wanxia.,...&Xiao, Yuling.(2023).Highly Twisted Conformation Thiopyrylium Photosensitizers for In Vivo Near Infrared-II Imaging and Rapid Inactivation of Coronavirus.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,11. |
| MLA | Liu, Yishen,et al."Highly Twisted Conformation Thiopyrylium Photosensitizers for In Vivo Near Infrared-II Imaging and Rapid Inactivation of Coronavirus".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2023):11. |
入库方式： OAI收割
来源：上海药物研究所
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