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Further undescribed cembranoids from South China Sea soft coral Sarcophyton ehrenbergi: Structural elucidation and biological evaluation

文献类型：期刊论文

作者Wu, Meng-Jun1,2,3; Yu, Dan-Dan5,6; Du, Ye-Qing3; Zhang, Juan4; Su, Ming-Zhi6; Jiang, Cheng-Shi4; Guo, Yue-Wei1,2,3,5,6
刊名PHYTOCHEMISTRY
出版日期2023-02-01
卷号206页码:9
ISSN号0031-9422
关键词Sarcophyton ehrenbergi Sarcophytidae Soft coral Diterpenoids Cembranoid ?-Glucosidase inhibitor
DOI10.1016/j.phytochem.2022.113549
通讯作者Su, Ming-Zhi(smz0310@163.com) ; Jiang, Cheng-Shi(bio_jiangcs@ujn.edu.cn) ; Guo, Yue-Wei(ywguo@simm.ac.cn)
英文摘要A detailed chemical investigation of the South China Sea soft coral Sarcophyton ehrenbergi has yield seven undescribed cembranoids, namely isoehrenbergol D and sarcoehrenolides F-K embodying a rare alpha,beta-unsaturated-lactone moiety at C-6 to C-19, along with two known related compounds, ehrenbergol D and sarcoehrenolide A. Their structures and absolute configurations were unambiguously established in the light of extensive spectro-scopic data analysis, modified Mosher's method, X-ray diffraction analysis, and quantum chemical computation method. In a bioassay for alpha-glucosidase inhibition, ehrenbergol D was evaluated as alpha-glucosidase inhibitor with an IC50 value of 13.57 mu M.
WOS关键词DITERPENOIDS ; CHEMISTRY
资助项目National Nat- ural Science Foundation of China ; SKLDR/SIMM Project ; [81991521] ; [82204240] ; [SIMM2013ZZ-06]
WOS研究方向Biochemistry & Molecular Biology ; Plant Sciences
语种英语
出版者PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号WOS:000903504400005
源URL[http://119.78.100.183/handle/2S10ELR8/303525]  
专题新药研究国家重点实验室
通讯作者Su, Ming-Zhi; Jiang, Cheng-Shi; Guo, Yue-Wei
作者单位1.Zhejiang Univ Technol, Collaborat Innovat Ctr Yangtze River Delta Reg Gre, Hangzhou 310014, Peoples R China
2.Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310014, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China
4.Univ Jinan, Sch Biol Sci & Technol, Jinan 250022, Peoples R China
5.Guangdong Med Univ, Coll Pharm, Zhanjiang 524023, Guangdong, Peoples R China
6.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Shandong, Peoples R China
推荐引用方式
GB/T 7714		 Wu, Meng-Jun,Yu, Dan-Dan,Du, Ye-Qing,et al. Further undescribed cembranoids from South China Sea soft coral Sarcophyton ehrenbergi: Structural elucidation and biological evaluation[J]. PHYTOCHEMISTRY,2023,206:9.
APA Wu, Meng-Jun.,Yu, Dan-Dan.,Du, Ye-Qing.,Zhang, Juan.,Su, Ming-Zhi.,...&Guo, Yue-Wei.(2023).Further undescribed cembranoids from South China Sea soft coral Sarcophyton ehrenbergi: Structural elucidation and biological evaluation.PHYTOCHEMISTRY,206,9.
MLA Wu, Meng-Jun,et al."Further undescribed cembranoids from South China Sea soft coral Sarcophyton ehrenbergi: Structural elucidation and biological evaluation".PHYTOCHEMISTRY 206(2023):9.

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来源：上海药物研究所

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