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Pseudotargeted Metabolomics Approach Enabling the Classification-Induced Ginsenoside Characterization and Differentiation of Ginseng and Its Compound Formulation Products

文献类型：期刊论文

作者Wang, Xiaoyan1,2; Jiang, Meiting1,2; Lou, Jia1,2; Zou, Yadan1,2; Liu, Meiyu1,2; Li, Zheng1,2,3; Guo, Dean1,2,4; Yang, Wenzhi1,2
刊名JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
出版日期2023-01-12
页码13
ISSN号0021-8561
关键词ginseng ginsenoside triple quadrupole-linear ion trap mass spectrometry classified identification pseudotargeted metabolomics identification marker
DOI10.1021/acs.jafc.2c07664
通讯作者Guo, Dean(daguo@simm.ac.cn) ; Yang, Wenzhi(wzyang0504@tjutcm.edu.cn)
英文摘要The use of diversified ginseng extracts in health-promoting foods is difficult to differentiate, as they share bioactive ginsenosides among different Panax species (e.g., P. ginseng, P. quinquefolius, P. notoginseng, and P. japonicus) and different parts (e.g., root, leaf, and flower). This work was designed to develop a pseudo-targeted metabolomics approach to discover ginsenoside markers facilitating the precise authentication of ginseng and its use in compound formulation products (CFPs). Versatile mass spectrometry experiments on the QTrap mass spectrometer achieved classified characterization of the neutral, malonyl, and oleanolic acid-type ginsenosides, with 567 components characterized. A pseudo-targeted metabolomics approach by multiple reaction monitoring (MRM) of 262 ion pairs could assist to establish key identification points for 12 ginseng species. The simultaneous detection of 14 markers enabled the identification of ginseng from 15 ginseng-containing CFPs. The pseudo-targeted metabolomics strategy enabled better performance in differentiating among multiple ginseng, compared with the full-scan high-resolution mass spectrometry approach.
WOS关键词PANAX-GINSENG ; LIQUID-CHROMATOGRAPHY ; FLOWER BUDS ; IDENTIFICATION ; TRITERPENOIDS ; QUINQUEFOLIUS ; DISCOVERY
资助项目National Natural Science Foundation of China[81872996] ; Tianjin Committee of Science and Technology of China[22ZYJDSS00040] ; Natural Science Foundation of Tianjin of China[20JCYBJC00060] ; Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine[ZYYCXTD-D-202002]
WOS研究方向Agriculture ; Chemistry ; Food Science & Technology
语种英语
出版者AMER CHEMICAL SOC
WOS记录号WOS:000916239900001
源URL[http://119.78.100.183/handle/2S10ELR8/303546]  
专题中国科学院上海药物研究所
通讯作者Guo, Dean; Yang, Wenzhi
作者单位1.Tianjin Univ Tradit Chinese, State Key Lab Component Based Chinese Med, Med, Tianjin 301617, Peoples R China
2.Tianjin Univ Tradit Chinese Med, Haihe Lab Modern Chinese Med, Tianjin 301617, Peoples R China
3.Tianjin Univ Tradit Chinese Med, Coll Pharmaceut Engn Tradit Chinese Med, Tianjin 301617, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Xiaoyan,Jiang, Meiting,Lou, Jia,et al. Pseudotargeted Metabolomics Approach Enabling the Classification-Induced Ginsenoside Characterization and Differentiation of Ginseng and Its Compound Formulation Products[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2023:13.
APA Wang, Xiaoyan.,Jiang, Meiting.,Lou, Jia.,Zou, Yadan.,Liu, Meiyu.,...&Yang, Wenzhi.(2023).Pseudotargeted Metabolomics Approach Enabling the Classification-Induced Ginsenoside Characterization and Differentiation of Ginseng and Its Compound Formulation Products.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,13.
MLA Wang, Xiaoyan,et al."Pseudotargeted Metabolomics Approach Enabling the Classification-Induced Ginsenoside Characterization and Differentiation of Ginseng and Its Compound Formulation Products".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2023):13.

入库方式： OAI收割

来源：上海药物研究所

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